In breast cancer target miRs
can be alleged oncogenes or tumor suppressor genes also found in various other cancers (Table-I) these include both circulating and non-circulating miRs
The findings obtained using a genomic profiling of miRNAs and mRNAs clearly showed that miR-193a-3p is one of the 12 miRs
found to be upregulated in the midsecretory phase samples.
reported that HMGA2, a target of miR
let-7, was upregulated in EC cells and was involved in EC carcinogenesis .
Evaluation of the Prognostic Role of miRs
Expression on Recurrence.
Surprisingly, none of the cardiac tissue relevant miRs
(miR-1, miR-133a, miR-208a/b, and miR-499)  are found to be affected by acute rejection.
were reverse-transcribed with the TaqMan MicroRNA Reverse Transcription Kit (Life Technologies) as described (23).
(2007), observed increased miR-10b expression in metastatic breast cancer and demonstrated that positive miR
regulation may confer potential for metastasis formation in nonmetastatic breast cancer cell lines.
Shaho Khan was the ancestor of the Shahwani Mirs
Recently, next generation sequencing has allowed us to accurately measure not only mRNA transcripts, but also regulatory noncoding RNA molecules such as microRNAs (miRs
) and long noncoding RNAs (lncRNAs).
Expression and localization of these structural proteins are known to be regulated by certain microRNAs (miRs
), such as miR-142-3p, which regulates Rac1 .
MicroRNAs (miRNAs o miRs
) are small noncoding RNAs involved in gene expression modulation, primarily silencing the mRNA target by binding its 31 -untranslated region (UTR) in the cytoplasm.
The common methodology to determine miRs
in various cases is ideally by northern blot analysis, but its drawback is that this procedure requires an increased quantity of blood, approximately 100ml, for proper results.6 A more convenient method that is being undertaken by researchers is real-time polymerase chain reaction (RT-PCR) and microarrays, but these are being conducted at research level to date due to its expense; it has not yet been used routinely as an investigation in commercial labs.