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MLK1Mixed Lineage Kinase 1 (enzyme)
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Recently, exome sequencing of metastatic melanoma cells reveals somatic mutations in the genes encoding ASK1 and another MAP3K, mixed lineage kinase 1 (MLK1).107) In the prevalent screen, mutations in the protein-coding regions of ASK1 and MLK1 are found in 9% and 15% of 85 melanoma cell lines examined, respectively, and are almost mutually exclusive.