Diagnosis of monoclonal gammopathy of renal significance. Kidney Int 2015; 87: 698-711, doi: 10.1038/ki.2014.408.
Monoclonal gammopathy of renal significance: diagnostic workup.
Monoclonal gammopathy of renal significance: when MGUS is no longer undetermined or insignificant.
Monoclonal gammopathy of renal significance (MGRS) increases the risk for progression to multiple myeloma: an observational study of 2935 MGUS patients.
Because the bone marrow examination showed 3.3% plasma cells and the patient had no features of hematologic malignancy, he was diagnosed with
monoclonal gammopathy of renal significance [5].
In the case of MPGN secondary to a monoclonal gammopathy the term MGRS (
monoclonal gammopathy of renal significance) should be used [17].
Three unrelated urine immunofixations, ordered for diagnostic purposes of
monoclonal gammopathy of renal significance (MGRS) (1, 2), exhibited several abnormal fractions in the protein electrophoresis lane (Fig.
C3GP: C3 Glomerulopathy; DDD: Dense Deposit Disease; ACP: Alternative Complement Pathway; MPGN: Membranoproliferative Glomerulonephritis; CRP: Complement Regulatory Proteins; MGRS: Monoclonal Gammopathy Of Renal Significance; Smac: Soluble Membrane Attack Complex
(2012) Monoclonal gammopathy of renal significance: when MGUS is no longer undetermined or insignificant.
Uncommon conditions reported in Table 1 have been recently grouped in the new entity of
monoclonal gammopathy of renal significance (MGRS) with the intent to discriminate the pathologic nature of these diseases from the truly benign MGUS [14].