Using cultured mouse neural stem cells
, the researchers identified the mechanism underlying EC-induced stem cell toxicity as "stress-induced mitochondrial hyperfusion," or SIMH.
The study published in the journal 'iScience' used cultured mouse neural stem cells
and identified the mechanism underlying EC-induced stem cell toxicity as 'stress-induced mitochondrial hyperfusion,' or SIMH.
Analyses in mouse neural stem cells
without the Sox2 gene showed that many of these genes were downregulated in the absence of SOX2 protein.
To test this idea, they transplanted mouse neural stem cells
into genetically modified mice exhibiting many of the key features of DLB.
In the new study, researchers tracked ubiquitin-studded proteins as mouse neural stem cells
divided into two cells: one remaining a stem cell and the other becoming a nerve cell, or neuron.
In 2003, Stefano Pluchino, MD, and Gianvito Martino, MD (San Raffaele Hospital, Milan) reported that immature nerve cells (adult mouse neural stem cells
, or neurospheres) injected into the blood or brain cavities of mice with EAE could move throughout the brain and spinal cord to sites of tissue damage, promote repair of nerve-insulating myelin, decrease damage to nerve fibers, and reverse clinical disease.
Gritti, The Neural Stem Cells and Their Transdifferentiation Capacity, 55 BIOMEDICINE & PHARMACOTHERAPY 201, 203 (2001); see also Rosella Galli et al., Skeletal Myogenic Potential of Human and Mouse Neural Stem Cells
, 3 NATURE NEUROSCI.
Cassady also refined the reprogramming cocktail to contain eight transcription factors, which produces iNSCs that are transcriptionally and cpigcnctically similar to mouse neural stem cells
Goldman's team found that certain classes of genes encoding for proteins active in mouse neural stem cells
- such as members of the Notch and WNT families - were highly active.
A Yu and Wang paper published in 2013 showed that GD3 is the predominant ganglioside in mouse neural stem cells
where it interacts with epidermal growth factor receptors, also found on the cell surface.
Mice genetically engineered to have Alzheimer's performed markedly better on memory tests a month after mouse neural stem cells
were injected into their brains.
In Quinones-Hinojosa's laboratory, the researchers examined the impact of radiation on mouse neural stem cells
by testing the rodents' responses to a subsequent brain injury.