The samples genotyping with real time PCR was carried out using "Real Time PCR kit for detection of MTHFR 677C>T, MTHFR 1298A>C, MTR 2756A>G, and MTRR
66A>G" (Sacace Biotechnologies, REF: T01002-96-S).
We hypothesize that genetic variants within the GSTM1/ GSTT1, CYP450, TP53, MTHFR, and MTRR
genes might be each linked alone or linked in combination with the occurrence of UBC.
In several transgenic mice model experiments, MTRR
gene with a hypomorphic mutation led to both embryo heart defect and hyperhomocysteinemia (hHcy) [17-19].
The researchers found that when either the maternal grandmother or the maternal grandfather had this Mtrr
mutation, their genetically normal grandchildren were at risk of a wide spectrum of developmental abnormalities.
* The most common cause of severe inherited hyperhomocysteinemia is cystathionine 0-synthase deficiency (homocystinuria type I), but other inherited causes should be considered, such as MTHFR deficiency and MTR (CblG) and MTRR
Different PUFAs have different effects on the mRNA expression of key genes involved in Hcy metabolism; n-3 PUFA upregulates expression, while n-6 PUFA down-regulates mRNA expression of Mthfr, Matla, Cbs, Pemt, Gnmt, Mtrr
, and Bad.
gonorrhoeae azithromycin resistance: the gene encoding the 23S ribosomal (rRNA) subunit (5), for which four alleles per genome exist, and the coding and promoter regions of the mtrR
gene (6), for which one allele per genome exists.
enzyme (methionine synthase reductase) is involved in restoration of MTR (methionine synthase) activity, the enzyme directly involved in homocysteine methylation.
The genes they have looked at are involved in the intracellular transport (reduced folate carrier 1 or RFC1), and conversion ([gamma] glutamyl hydrolase or GGH) of methotrxate, metabolism of purine and pyrimidine (methylenetetrahydrofolate reductase or MTHFR, thymidylate synthase or TS, methionine synthase or MS, serine hydroxymethyltransferase I or SHMT 1 , aminoimidazol carboxamide ribinucleotide transformylase or ATIC, methionine synthase reductase or MTRR
) and efflux of the drug (multidrug resistance protein 1 or MDR1).
Amac: Bu calismada metiyonin sentaz (MTR) ye metiyonin sentaz reduktaz (MTRR
) A2756G ve A66G gen polimorfizmlerinin infertilite ile Hiskisinin olup olmadigi arastinlmtstir.
Methylenetetrahydrofolate Reductase (MTHFR) 677C[flecha diestra]T and Methionine Synthase Reductase (MTRR
) 66A[flecha diestra]G Polymorphisms: Association with Serum Homocysteine and Angiographic Coronary Artery Disease in the Era of Flour Products Fortified with Folic Acid.