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References in periodicals archive ?
Inactivation of myeloperoxidase by EGCG may be beneficial in mitigating IBD flare-ups.
Currently, Biohaven's lead development programs include multiple compounds across its CGRP receptor antagonist, glutamate modulation, and myeloperoxidase inhibitor platforms.
The biomarkers can be used for patient education; for instance, a young patient with high F2-isoprostanes can see that they have oxidative stress in their arteries, or a 13-year-old with dysfunctional HDL due to high myeloperoxidase can be shown to be at a significant risk for metabolic syndrome.
Significantly high levels of plasma malondialdehyde, nitric oxide, myeloperoxidase, adenosine deaminase and cytokines and significantly low levels in total antioxidant capacity and glutathione levels were found in dogs with leishmaniasis when compared with the healthy controls.
Positivity of histiocytes for myeloperoxidase is a helpful clue.
(NYSE: BHVN) has entered into an exclusive, worldwide license agreement, through its subsidiary Biohaven Therapeutics Ltd., with AstraZeneca AB for the development and commercialization rights to AZD3241, an oral myeloperoxidase inhibitor that AstraZeneca progressed through Phase 2 clinical trials, the company said.
Myeloperoxidase is an important enzyme that is found in neutrophils, and it is involved in the ROS production (26, 27).
The analysis was adjusted by age, by the traditional risk factor LDL/HDL ratio, by the non-traditional risk factors pulse pressure and neck circumference, and by the inflammatory marker myeloperoxidase. The multiple linear regression revealed a significant association of c-IMT with uric acid and an even stronger association with allantoin.
Further, an immunofluorescence study of NETs showed that NETs consist of azurophilic (primary) granules such as cathepsin G, neutrophil elastase, and myeloperoxidase. Secondary and tertiary granules such as lactoferrin and gelatinase, respectively, were also found in NETs [1].
CD68, a panhistiocytic marker, and myeloperoxidase, a marker of myeloid cells, were diffusely expressed in lesional cells with histiocytic morphology.