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N-9Nonoxynol9 (spermicide)
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Christine Mauck said these findings are consistent with earlier observations that the differences in lesions between placebo and N-9 are seen only in frequent users.
"I think the bottom line is that N-9 may be safe in those women who don't use it frequently and who are at low risk for HIV and STIs, and that's probably a lot of the women we see in our practices.
Centers for Disease Control and Prevention (CDC) published similar recommendations, advising family planning providers to inform women at risk of HIV and other STIs that N-9 spermicides do not protect against these infections.
The WHO and CDC recommendations are based, in part, on an analysis of 10 randomized clinical trials of the effectiveness of N-9 against HIV or other STIs, involving almost 5,000 women, that included trials conducted by the Joint United Nations Programme on HIV/AIDS (UNAIDS) and FHI.
Whether N-9 adds contraceptive protection to barrier methods other than condoms is still unknown, although spermicide use with the diaphragm is recommended.
The Centers for Disease Control states: "N-9 can damage the cells lining the rectum, thus providing a portal of entry for HIV and other sexually transmissible agents.
The World Health Organization states: "N-9 should not be used rectally." (Further) "There is no published scientific evidence that N-9-lubricated condoms provide any additional protection against pregnancy or STIs compared with condoms lubricated with other products.
Data on the percentage of condoms lubricated with N-9 were not available.
Editorial Note: The findings in this report indicate that in 1999, before the release of recent publications on N-9 and HIV/STDs (4,6,7), Title X family planning clinics in the U.S.
After presentation of the preliminary results from the study in July 2000, the World Health Organization (WHO) was approached to provide an assessment of the scientific information regarding the safety and effectiveness of N-9 when used for family planning purposes.
This report summarises the evidence presented to the meeting on the safety of N-9 and its effectiveness for protection against pregnancy, sexually transmitted infections (STIs) and HIV.
are lubricated with N-9, and about 40% of gay men look for it.
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