To study the role of Sertoli-germ cell interactions in DBP-induced germ cell aggregation, we examined expression of cell-cell adhesion molecules, APC, espin, vimentin, and N-cadherin
(Bartles et al.
Conversely, all esophageal adenocarcinomas (100%; 24 of 24) were negative with N-cadherin
versus 42% of lung adenocarcinomas (10 of 24), which showed some staining.
(neural cadherin) is associated with heightened invasive potential in cancer.
Scientists in Bristol have now produced a smaller, soluble form of N-cadherin
that has the ability to stabilise plaques.
E-cadherin, which inhibits cancer cell migration and invasion, was reduced in B[a] P-treated groups relative to the control group, but expression of metastasis-promoting proteins, including N-cadherin
, vimentin, snail, and slug, were induced after B[a]P exposure (Figure 2F).
In aggressive tumors, EMT is characterized by reduced expression of E-cadherin and increased N-cadherin
expression, which contributes to a more stromal cellular adhesion profile and increased tumor cell motility and invasive properties.
The findings support a critical role for N-cadherin
in pancreatic ductal adenocarcinma (PDA).
Expression of N-cadherin
by human squamous carcinoma cells induces a scattered fibroblastic phenotype with disrupted cell-cell adhesion.
This Phase II single agent trial, which is ongoing at the Ottawa Regional Cancer Centre, the Princess Margaret Hospital in Toronto and the Jewish General Hospital in Montreal, is designed to evaluate the anti-tumor activity and tolerability of repeated doses of ADH-1 in patients whose tumors express the molecular target N-cadherin
The differential expression of N-cadherin
and E-cadherin distinguishes pleural mesotheliomas from lung adenocarcinomas.
Comparison of Mesothelioma and Adenocarcinoma Procedure Mesothelioma Special stains Alcian blue + (hyaluronidase-sensitive) Colloidal iron + (hyaluronidase-sensitive) Mucicarmine -- Periodic acid--Schiff -- Immunohistochemistry Calretinin + Cytokeratin 5/6 + Thrombomodulin + HBME-1 + CD44S + N-cadherin
+ MOC13 -- BG-8 -- Carcinoembryonic antigen -- Leu-M1 (CD15) -- E-cadherin -- Ber-EP-4 -- B72.
E-cadherin was most frequently expressed (34/35, 97%), followed in frequency by N-cadherin
(22/35, 63%) and P-cadherin (15/35, 43%).