ESSA's proprietary 'aniten' compounds bind to the N-terminal domain
of the androgen receptor ('AR'), inhibiting AR driven transcription and the AR signaling pathway in a unique manner which bypasses the drug resistance mechanisms associated with current anti-androgens.
Her expertise will be instrumental in advancing the clinical development of ESSA's novel N-terminal domain
inhibitor of the androgen receptor in men with prostate cancer.'
We have preliminary evidence suggesting that the distal portion of the AMPA-R, the N-terminal domain
(or NTD) regulates receptor diffusion/retention and clustering at post-synaptic sites.
The gene is translated into a protein known with three functional domains, including the N-terminal domain
(NTD), the DNA binding domain (DBD) and the C-terminal ligand binding domain (LBD).
The LIG_MDM2 motifs matched with FSFLWRGL (253-260) functional residue of p53 family members, which confers binding to the N-terminal domain
of MDM2 in the nucleus.
Nrf1 and Nrf3 exhibit a N-terminal domain
(NTD) with a transmembrane region to anchor proteins to the ER membrane.
Like other Annexins, Anxa2 protein of sika deer had the typical structure of Annexin, containing a highly conserved C-terminal core domain and a relative flexible N-terminal domain
In addition, the class 1 isoform also has an N-terminal domain
The domains contain divergent insertions between the fourth [beta]-strand and first [alpha]-helix: the N-terminal domain
's insertion forms a three-stranded [beta]-sheet, and the C-terminal domain's insertion contributes a short helix to the helical core and forms an [alpha]/[beta]-subdomain [35-37].
Their results suggested that the N-terminal domain
is indispensable for NbFib2 to target the nucleolus and cajal body, p2 binds to all three regions of NbFib2, and they target to the nucleus but fail to target the nucleoli and cajal bodies.
The Myc (N-terminal domain
) contains a conserved Myc boxes (boxes I, II followed by III, IV) and a nuclear targeting sequence (Cowling and Cole, 2007).
Among the 22 Chinese patients with CMT1X, the frequency of the GJB1 mutation was 4.5% in transmembrane domain 1 (TM1), 4.5% in TM2, 22.7% in TM3, 9.1% in TM4, 4.5% in extracellular 1 (EC1), 27.3% in EC2, 9.1% in intracellular loop, 13.6% in the N-terminal domain
, and 4.5% in the C-terminal domain.