indicates that metastasis in multiple ipsilateral lymph nodes were present, none >6 cm.
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CLINICOPATHOLOGICAL DATA Follow- Alive, Patient pN ECS pT PNI Margin up (mo.) Recurrence AWD,DOD 1 N2b
+ T3 + + 60 - Alive 2 N0 T4 + - 27 - DOD 3 N2c + T4 + + 36 Cervical DOD 4 N0 T4 - - 67 - Alive 5 N1 - T4 - - 9 Cervical DOD 6 N0 T4 + - 23 Local, cervical DOD 7 N2c + T4 + - 8 Local DOD 8 N1 + T3 + + 24 Local, cervical DOD pN, pT = pathological TNM stage; ECS = extracapsular spread; PNI = perineural invasion; AWD = alive with disease; DOD = dead of disease.
Similar negative waves were distinguished by Arezzo and Vaughan (1980) before movement in extremities in subdural registration in monkeys and noted as N2a and N2b
. These authors suggested that the first potential is related to the initiation of movement, whereas the second one reflects signals of afferent feedback from extension and joint receptors.
Stage (cGy) Fractions 1 T2A NO MO 6600 33 2 T2 N2b
Mx 5500 25 3 T3 NO 6600 33 4 N/A 5000 33 5 T1 NO MO 6600 33 5000 25 6 T2 N1 6600 33 7 N/A 6000 33 POP/ant split=parallel opposed/anterior split.
CLINICAL STAGING PATHOLOGIC STAGING 5-YEAR SURVIVAL (%) 0 Tis N0 M0 Tis N0 M0 96-100 IA T1a N0 M0 T1a N0 M0 95 IB T1b N0 M0 T1b N0 M0 90 T2a N0 M0 T2a N0 M0 IIA T2b N0 M0 T2b N0 M0 78 T3a N0 M0 T3a N0 M0 IIB T3b N0 M0 T3b N0 M0 65 T4a N0 M0 T4a N0 M0 IIC T4b N0 M0 T4b N0 M0 45 III Any T Any N M0 IIIA T1-4a N1a M0 66 T1-4a N2a M0 IIIB T1-4b N1a M0 52 T1-4b N2a M0 T1-4a N1b M0 T1-4a N2b
M0 T1-4a N2c M0 T1-4b N2c M0 IIIC T1-4b N1b M0 26 T1-4b N2b
M0 Any T N3 M0 IV Any T Any N Any M Any T Any N Any M 7.5-11 TABLE 2 Recommended incision margins BRESLOW THICKNESS EXCISION MARGINS (CM) In situ 0.5 <1 mm 1 1-4 mm 1-2 >4 mm 2-3
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IIIb = N1b or N2b
(up to three nodes with macroscopic disease)
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