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Regarding NADCs, longer duration of HIV infection, type 2 HIV, higher mean CD4 cell count and a longer history of HAART were the most significantly associated factors.
An interesting finding of this study included the association of older age, type 2 HIV, longer duration of HIV infection, higher mean CD4 cell count and history of HAART with NADCs. Primarily, it is interesting to note the enormous ethnic diversity and the consequent prevalence of type 2 HIV, diagnosed not only in the Infectious Diseases Department of Hospital de Santa Maria, but also in Portugal, corresponding to 3.1% of HIV infections.
Several studies in the HAART era (17,25,26) have failed to find an association between CD4 cell count and NADCs, even though the latest data (24) show an association between immunosuppression and an increased risk of incidence of certain NADCs, but not all.
Smoking was not associated with NADCs-IUR, even if borderline significant association was observed with all NADCs and lung carcinoma had been one of the most frequent malignancies in this group.
Older patients, with longer duration of HIV infection and longer history of HAART appeared to be more predisposed to develop certain malignancies, particularly NADCs.
Despite an evident multifactorial etiology, while ADCs were significantly associated with immunosuppression, NADCs appeared to be related to other oncogenic mechanisms such as chronic inflammation.
Malignancies divided by AIDS-defining cancers (ADCs) and non-AIDS-defining cancers (NADCs) and summarized by gender, from a sample of 25 HIV-infected patients.
All NADC cases were diagnosed in the HAART era and from 2003 to 2010 (except for one).
From the 12 NADC cases, which accounted for 48% of all malignancies, seven cases (28% of all malignancies) and five cases (20% of all malignancies) were NADCs-IUR and NADCs-IR, respectively (figure 1).