NASRNNational Anatolian Shepherd Rescue Network
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On multivariate analysis, after adjusting for age, gender, histology, grade, TNM status, tumour necrosis and vascular invasion, there was a trend (although did not reach statistical significance) towards worse OS (hazard ratio [HR] 1.759, 95% CI 0.943-2.309, p = 0.089) and CSS (HR 1.797, 95% CI 0.967-3.337, p = 0.064) in patients with NASRN.
In this observational study in patients treated primarily with either ASRN or NASRN, with a 13-year follow-up, ASRN was associated with better survival than NASRN among patients with non-metastatic clear cell RCC.
Accepting the fact that a prospective randomized trial is impractical in this scenario, we found that our observational study with a 13-year follow-up suggests that ASRN leads to better survival than NASRN. ASRN should be considered the gold standard in patients with RCC, unless it is contraindicated.