, UGT1A10, and GSTP1 were expressed moderately to highly
Yamanaka wanted to study mice that lacked NAT1
to see whether they would still develop cancer.
Effect of NAT1
and NAT2 genetic polymorphisms on colorectal cancer risk associated with exposure to tobacco smoke and meat consumption.
N-acetyltransferase-1 (NAT1) and N-acetyltransferase-2 (NAT2) are encoded by NAT1 and NAT2 in human chromosome 8 (Blum et al.
2 mM dNTP mix, 20 pmol of each primer (B-MDIEA-NAT1 & VPKHGD-X-NAT1 for NAT1, FP1-NAT2 & RP1-NAT1 for NAT2, Act b1 & Act b2 for beta-actin), cDNA template corresponding to the amount synthesized from 50 ng of total RNA and 2 units of DyNAzyme DNA polymerase.
The coefficient for NAT1
, the control variable for Korean subsidiaries of US MNCs, is statistically significant and positive.
2 mM dNTP mix, 20 pmoles of each primer (B-MDIEA-NAT1
, FP1-NAT2 & RP1-NAT2 for NAT2, Act b1 & Act b2 for beta-actin), cDNA template corresponding to the amount synt hesized from 50 ng of total RNA and 2 units of DNA polymerase.
We believe that the discrepancies between phenotypes and genotypes suggest possible problems in phenotyping or the presence of another factor that contributes to the variability in NAT2 activity, such as the NAT1
We found that human NAT1
was rapidly and irreversibly inhibited by Cd [median inhibitory concentration ([IC.
Amplification was done in two steps, primary and secondary PCBs, to differentiate NAT2 from its family member gene NAT1
This is exemplified in Figure 3 where the dashed gray line represents the risk profile for the most common genotypes modeled from the 12 asthma susceptibility genes (group 1 variants) and the solid blue line shows the risk profile when the NAT1
variant is added.
1998) provided evidence for a three-way interaction between NAT2, NAT1
, and smoking that modifies bladder cancer risk such that individuals who smoke and have NAT2 slow acetylator alleles in combination with the high-activity NVAT1*10 allele (homozygotes or heterozygotes) have heightened bladder cancer risk.