NAT1N-Acetyl Transferase 1
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Most of the investigations of NAT as a susceptibility factor in cancer have involved NAT2 polymorphism as it has been better characterized than NAT1 polymorphism (Wohlleb et al., 1990; Hein, 2002).
Lack of association between endometriosis and N-acetyl transferase 1 (NAT1) and 2 (NAT2) polymorphisms in a Japanese population.
specimen, NAT1, UGT1A10, and GSTP1 were expressed moderately to highly
Peroxynitrite Irreversibly Inactivates the Human Xenobioticmetabolizing Enzyme Arylamine N-Acetyltransferase 1 (NAT1 ) in Human Breast Cancer Cells A Cellular and Mechanistic Study.
Two package insert biomarkers (NAT1 and NAT2, 7.7%) were not found in any resource, and 57.7% (15/26 biomarkers) were found in all the resources: C-Kit, CCR5, chromosome 5q, CYP2C9, CYP2C19, CYP2D6, EGFR, estrogen receptor, G6PD, Her2/Neu, HLA-B*5701, Philadelphia chromosome, PML/RARa translocation, TPMT, and UGT1A1.
Neste periodo experimental, somente os grupos treinados (NAT1 e CRE+NAT1) apresentaram elevacoes plasmaticas estatisticamente iguais (p < 0,05) de CQ, LDH e AST, corroborando os achados da literatura pelos autores sobre a relacao destes marcadores com a producao elevada das mesmas apos treinamentos prolongados e intensos.
Arylamine N-acetyltransferases (NATs), EC are found in almost all species from bacteria to humans (Butcher et al., 2002) and exist as two polymorphic forms as N-acetyltransferase 1 (NAT1) and N-Acetyltransferase 2 (NAT2), both involved in drug and/or chemicals metabolism.
Hens were provided with one of the following dietary treatments: i) Positive Control (PC; available phosphorus (AP) 0.4%); ii) Negative Control (NC; AP 0.2%); iii) NAT1 (NC+250 FTU/kg NAT); iv) NAT2 (NC+250 FTU/kg NAT); v) OPT1 (NC+250 FTU/kg OPT); vi) OPT2 (NC+250 FTU/kg OPT).
Using the DNA extracted from the babies and their parents, the researchers looked at the genes related to detoxification of chemicals in cigarette smoke (NAT1, NAT2, CYP1A1, GSTP1, GSTT1, GSTM1).
variants CYP450 CYP1A2 6 CYP2A6 7 CYP2B6 10 CYP2C19 12 CYP2C8 4 CYP2C9 10 CYP2D6 18 CYP2E1 1 CYP2J2 5 CYP3A4 2 CYP3A5 8 Non-CYP enzymes CDA 2 DPYD 6 FMO2 1 FMO3 2 GSTP1 2 NAT1 12 NAT2 7 TPMT 5 UGT1A1 9 Transporters ABCB1 6 ABCC2 6 SLCO1B1 9 SLCO2B1 1 SLC15A2 4 SLC22A1 6 SLC22A2 4 (a) Variants tested include SNPs, insertions, deletions, triallelic variants, and nucleotide repeats.