Most of the investigations of NAT as a susceptibility factor in cancer have involved NAT2 polymorphism as it has been better characterized than NAT1
polymorphism (Wohlleb et al., 1990; Hein, 2002).
Lack of association between endometriosis and N-acetyl transferase 1 (NAT1
) and 2 (NAT2) polymorphisms in a Japanese population.
, UGT1A10, and GSTP1 were expressed moderately to highly
Peroxynitrite Irreversibly Inactivates the Human Xenobioticmetabolizing Enzyme Arylamine N-Acetyltransferase 1 (NAT1
) in Human Breast Cancer Cells A Cellular and Mechanistic Study.
Two package insert biomarkers (NAT1
and NAT2, 7.7%) were not found in any resource, and 57.7% (15/26 biomarkers) were found in all the resources: C-Kit, CCR5, chromosome 5q, CYP2C9, CYP2C19, CYP2D6, EGFR, estrogen receptor, G6PD, Her2/Neu, HLA-B*5701, Philadelphia chromosome, PML/RARa translocation, TPMT, and UGT1A1.
Further research refined his theory: he found that switching on APOBEC-1 in the liver altered NAT1
, a protein that, when modified, causes tumors to develop.
Neste periodo experimental, somente os grupos treinados (NAT1
e CRE+NAT1) apresentaram elevacoes plasmaticas estatisticamente iguais (p < 0,05) de CQ, LDH e AST, corroborando os achados da literatura pelos autores sobre a relacao destes marcadores com a producao elevada das mesmas apos treinamentos prolongados e intensos.
Arylamine N-acetyltransferases (NATs), EC 188.8.131.52 are found in almost all species from bacteria to humans (Butcher et al., 2002) and exist as two polymorphic forms as N-acetyltransferase 1 (NAT1
) and N-Acetyltransferase 2 (NAT2), both involved in drug and/or chemicals metabolism.
Hens were provided with one of the following dietary treatments: i) Positive Control (PC; available phosphorus (AP) 0.4%); ii) Negative Control (NC; AP 0.2%); iii) NAT1
(NC+250 FTU/kg NAT); iv) NAT2 (NC+250 FTU/kg NAT); v) OPT1 (NC+250 FTU/kg OPT); vi) OPT2 (NC+250 FTU/kg OPT).
Using the DNA extracted from the babies and their parents, the researchers looked at the genes related to detoxification of chemicals in cigarette smoke (NAT1
, NAT2, CYP1A1, GSTP1, GSTT1, GSTM1).
Maternal smoking and the risk of orofacial clefts: Susceptibility with NAT1
and NAT2 polymorphisms.
variants CYP450 CYP1A2 6 CYP2A6 7 CYP2B6 10 CYP2C19 12 CYP2C8 4 CYP2C9 10 CYP2D6 18 CYP2E1 1 CYP2J2 5 CYP3A4 2 CYP3A5 8 Non-CYP enzymes CDA 2 DPYD 6 FMO2 1 FMO3 2 GSTP1 2 NAT1
12 NAT2 7 TPMT 5 UGT1A1 9 Transporters ABCB1 6 ABCC2 6 SLCO1B1 9 SLCO2B1 1 SLC15A2 4 SLC22A1 6 SLC22A2 4 (a) Variants tested include SNPs, insertions, deletions, triallelic variants, and nucleotide repeats.