NAT2N-Acetyl Transferase 2
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The results indicate that anthropogenic forcing leads to a marked increase in the event occurrence although there is a certain degree of uncertainty induced by the different estimations of anthropogenic changes in SST and sea ice between NATI and NAT2.
Lack of NAT2 function is associated with higher incidences of cancer and drug toxicity.
Meat and heterocyclic amine intake, smoking, NAT1 and NAT2 polymorphisms, and colorectal cancer risk in the multiethnic cohort study.
El gen NAT2 codifica para la enzima Arilamina N-acetiltransferasa 2 (NAT2), la cual interviene en la fase II de la detoxification metabolizando xenobioticos y componentes que contienen aminas aromaticas por N- u O-acetilacion; ademas, metaboliza antibioticos como la Isoniacida que se utiliza en el tratamiento contra la Tuberculosis (1-3).
2006) The role of Gilbert's syndrome and frequent NAT2 slow acetylation polymorphisms in the pharmacokinetics of retigabine.
Dietary isothiocyanates, GSTM1, GSTT1, NAT2 polymorphisms and bladder cancer risk.
The prevalence of the genetic polymorphism of CyP1A1, CYP3A5, PON1, GSTM1, GSTT1, GSTP1 and NAT2 xenobiotic polymorphism was significantly same in pesticide exposed and control subjects.
The N-Acetyltransferase 2 (NAT2) polymorphism is one of the most common inherited variations in the biotransformation of drugs and chemicals and large number of studies has been done to determine the distribution of NAT2 acetylator phenotypes among populations of different geographic origins.
Polymorphisms at XPD and XRCC1 DNA repair loci and increased risk of oral leukoplakia and cancer among NAT2 slow acetylators.
2%); iii) NAT1 (NC+250 FTU/kg NAT); iv) NAT2 (NC+250 FTU/kg NAT); v) OPT1 (NC+250 FTU/kg OPT); vi) OPT2 (NC+250 FTU/kg OPT).
Using the DNA extracted from the babies and their parents, the researchers looked at the genes related to detoxification of chemicals in cigarette smoke (NAT1, NAT2, CYP1A1, GSTP1, GSTT1, GSTM1).