NAT2N-Acetyl Transferase 2
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The best estimate in occurrence probability (95% CI) of the extreme DSW index that falls below the threshold is 1.3% (0.0-3.4%), 0.17% (0.0-0.51%), 0.046% (0.0-0.40%), and 0.11% (0.0-0.40%) for ALL, NAT1, NAT2, and ALLnoENSO, respectively (Fig.
Most of the investigations of NAT as a susceptibility factor in cancer have involved NAT2 polymorphism as it has been better characterized than NAT1 polymorphism (Wohlleb et al., 1990; Hein, 2002).
We deem that this topic appears extremely interesting, but at the same time controversial: it is known that NAT2 enzyme has a critical role in the initial biotransformation of multiple xenobiotic substances (among all aromatic amines and hydrazines) and that several polymorphisms and alleles of its gene characterize the genome of general population (with different distribution in the world) (2).
Alcohol, smoking, and caffeine in relation to fecundability, with effect modification by NAT2. Ann Epidemiol 2011; 21(11): 864-872 [CrossRef]
The NAT2 functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens.
In turn, patient number 1 possessed four polymorphisms connected with drug metabolism (CYP2C19 c.681G>A(p.=), CYP2C9 p.Ile359Leu, NAT2 p.Ile114Thr, and NAT2 p.Arg197Gln), out of which CYP2C9 p.Ile359Leu is of particular importance since it leads to impaired metabolism of widely available nonsteroidal anti-inflammatory drugs [42, 43].
Pathology Genes Orofacial clefts CL/P BMP4 CRISPLD2 FGF8 FGFR1 FGFR2 FOXE1 GLI2 GSTM1 GSTT1 JAG2 LHX8 MSX1 MSX1 MSX2 NAT1 NAT2 PTCH PVRL1 RYK SATB2 SKI SPRY2 TBX10 TGFB3 ATM Papillary thyroid cancer NKX2 RET (RET/PTC rearrangement) DFNB31 Hypothyroidism PTPN22 SH2B3 VAV3
Anti-histone antibodies were elevated at 2.8 units (>1.5 is positive) and her N-acetyltransferase 2 (NAT2) genotype was found to be "intermediate acetylator."
In this respect, a case-control study carried out in European countries investigated polymorphisms with relevance to brain expression and metabolism of substances contained in tobacco smoke and confirmed significant interactions of SNPs in cytochrome P-450 enzyme family genes (GSTM1, GSTP1, and NAT2).
Laarabi et al., "Distribution of allelic and genotypic frequencies of NAT2 and CYP2E1 variants in Moroccan population," BMC Genetics, vol.
revealed that panel of hypermethylated genes, for example, DCC, CSPG2, and NAT2, was specific to HBV-related HCC [26, 27] and methylation of constitutive androstane receptor (CAR) suppresses CYP2C19 in HBV-associated HCC patients [28].
Association between dietary heterocyclic amine levels, genetic polymorphisms of NAT2, CYP1A1, and CYP1A2 and risk of colorectal cancer: a hospital-based case-control study in Japan.