NBD1Nucleotide-Binding Domain 1
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References in periodicals archive ?
The most common CF mutation is the deletion of a phenylalanine at amino acid position 508 in the NBD1 domain of CFTR protein (F508del) [22].
As SUR1 exon 17 encodes part of NBD1 which is required for nucelotide handling, it seems likely that a protein lacking this crucial regulatory domain would have an altered sensitivity to ATP.
The core structure of an ABC protein consists of MSD1, NBD1, MSD2, and NBD2; however, SUR1/ABCC8 contains an additional MSD0.