NBD1 - What does NBD1 stand for? The Free Dictionary
References in periodicals archive
The most common CF mutation is the deletion of a phenylalanine at amino acid position 508 in the NBD1
domain of CFTR protein (F508del) .
As SUR1 exon 17 encodes part of NBD1
which is required for nucelotide handling, it seems likely that a protein lacking this crucial regulatory domain would have an altered sensitivity to ATP.
The core structure of an ABC protein consists of MSD1, NBD1
, MSD2, and NBD2; however, SUR1/ABCC8 contains an additional MSD0.