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Wan et al., "The NBS1 genetic polymorphisms and the risk of the systemic lupus erythematosus in Taiwanese patients," Journal of Clinical Immunology, vol.
Teng, "Importin KPNA2 is required for proper nuclear localization and multiple functions of NBS1," The Journal of Biological Chemistry, vol.
To improve the oleophilic and hydrophobic properties of bagasse for oil spill cleanup raw bagasse mesh number 30 was selected and modified by acetylation reaction with acetic anhydride using NBS1 as a catalyst under mild conditions .
In eukaryotes a third accessory protein (Nbs1 or Xrs2) is present to form MRN or MRX complexes, respectively.
Harbour, "NBS1 expression as a prognostic markerin uveal melanoma," Clinical Cancer Research, vol.
Kobayashi, "Molecular mechanism of the recruitment of NBS1/hMRE11/hRAD50 complex to DNA double-strand breaks: NBS1 binds to [gamma]-H2AX through FHA/BRCT domain," Journal of Radiation Research, vol.
One of the recent recognized sensor protein complexes that regulates DNA damage repair is MRE11 complex consist of meiotic recombination 11 (MRE11), Rad50, Nijmegen Breakage Syndrome 1 (NBS1) (Petrini and Stracker, 2003).
Subsequently, several downstream substrates, such as P53 and ChK2, and DNA repair factors, such as H2AX and NBS1, are activated (24).
Note exquisite sensitivity in cell strains derived from DNA damage sensing- or repair-deficient cells derived from patients with abnormal ATM, NBS1 and DNA ligase IV proteins.
To find out, Tainer and Russell produced a series of high-resolution images of the crystal structure of parts of all three proteins (rad50, Mre11, and Nbs1), taken from fission yeast and archaea.
MRE11, RAD50, and NBS1 Gene Expression in Breast Cancer Progression.
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