(NASDAQ: RTRX) today announced that it has entered into a three-way Cooperative Research and Development Agreement (CRADA) with the National Institutes of Health's National Center for Advancing Translational Sciences (NCATS
) and patient advocacy foundation Alagille Syndrome Alliance (ALGSA) to collaborate on research efforts aimed at the identification and development of potentially novel therapeutics for Alagille syndrome (ALGS).
Through collaboration with patients, families and our other stakeholders, NCATS
is helping to bring more treatments to more rare diseases patients more quickly." Petra Kaufmann, M.D., M.Sc., director of the Office of Rare Diseases Research at NCATS
In 2012, NCATS
, an arm of the National Institutes of Health, launched a program called Discovering New Therapeutic Uses for Existing Molecules that makes proprietary drugs that have undergone significant research and development by pharmaceutical companies available to academic researchers.
' drug repurposing screening robots, researchers identified two classes of compounds effective against Zika.
To gauge the potential efficacy of a megafund, the authors used data from two of NCATS
' rare diseases programs to evaluate the risks and rewards of a simulated portfolio calibrated according to data from 28 active projects funded and managed by NCATS
By bringing these institutions together, NCATS
has created an environment in which the three entities can build off of each other's strengths--a triune synergy--that has and will continue to make a positive impact on drug repurposing projects, biomedical research, and global health.
is the home for two pilot programs focusing on drug repurposing and rescue.
NIH's new National Center for Advancing Translational Sciences (NCATS
) has partnered initially with Pfizer Inc., AstraZeneca PLC and Eli Lilly and Co., which have agreed to make dozens of their compounds available for this initiative's pilot phase.
In FY 2012, NIH plans to establish the National Center for Advancing Translational Sciences (NCATS
) as a mechanism for bridging the gap between basic science and therapeutic applications.
Parts of the NCAST, the Nursing Child Assessment Feeding Scale (NCAFS) and the Nursing Child Assessment Teaching Scale (NCATS
) look at caregiver/child interaction and are used for early case-finding and intervention.