The highly conserved corepressor MINT contains an essential SPOC (Spen Paralog and Ortholog C-terminal) domain, which binds additional corepressors such as NCoR
(Nuclear Receptor CoRepressor) to completely repress Notch target genes.
Additionally, SUMOylation also induces recruitment of PPAR corepressors, such as NCoR
as depicted in Figure 2.
- Gene duplication, although the total number of genes in the genome doesn't vary significantly, some specific genes duplicate one or more times, for example there is one NCoR
gene in sea urchin and two in humans.
The nuclear receptor corepressors NCoR
and SMRT decrease peroxisome proliferator-activated receptor gamma transcriptional activity and repress 3T3-L1 adipogenesis.
Interestingly PPAR-[gamma] was the first reported to undergo agonist-dependent simulation, which promotes binding to nuclear receptor co-repressor-1 protein (NCoR
) and stabilizes association with promoter-bound NF-[kappa]B, thereby leading to the transrepression of inflammatory genes in macrophages [86-88].
COUP-TF family members play important roles in development, (16) and they usually mediate transcriptional repression by recruiting nuclear receptor co-repressor (NCoR
) and/or silencing mediator for retinoid and thyroid hormone receptor (SMRT) to the template.
Their research revealed a new and previously unsuspected role for nuclear receptor corepressor (NCoR
), a transcriptional coregulatory protein found in a wide variety of cells.
Two well-characterized AR corepressors are NCoR
(nuclear receptor corepressor) and its homolog SMRT (silencing mediator for retinoid and thyroid hormone receptors) (39).
In the absence of ligand, RAR-RXR in normal blasts and PML-RAR[alpha]-RXR heterodimers in APL cells recruit nuclear co-repressor proteins, NCoR
or silencing mediator of retinoid and thyroid hormone receptor (SMRT), and Sin3A or Sin3B, which in turn form a complex with histone deacetylase enzymes (HDAC1 or HDAC2), resulting in transcriptional repression or silencing [36-38] (Figure 3A and B).
[H.sub.1] : max [absolute value of ncor
([[??].sup.(r)],[w.sup.(q)])] [greater than or equal to] Th Decode q