For this purpose EGR2, MPZ, PMP22, CX32, HSP22, HSP27, LITAF, LMNA, MFN2,
NEFL and HSN2 were screened and we did not found any mutation.
Genes near the genome-wide significant loci included TMEM65, NEFM,
NEFL, AGPAT4, and PARK2.
Abbreviations ALS: Amyotrophic lateral sclerosis BM: Bone marrow BME: [beta]-Mercaptoethanol DAPI: Dihydrochloride DMEM: Dulbecco's modified Eagle's medium DMSO: Dimethyl sulfoxide FACS: Fluorescence-activated cell sorting FBS: Fetal bovine serum FOV: Field of view GDNF: Glial cell line-derived neurotrophic factor GFAP: Glial fibrillary acidic protein MAP2: Microtubule-associated protein 2 miR: MicroRNA MSCs: Mesenchymal stem cells
NEFL: Neurofilament, light polypeptide NSE: Neuron-specific enolase PADM: Porcine acellular dermal matrix PBS: Phosphate-buffered saline PFA: Paraformaldehyde RFP: Red fluorescent protein rGO: Reduced graphene oxide RT-PCR: Reverse transcription polymerase chain reaction T[alpha]1: Tubulin [alpha]1.
The human neurofilament gene (
NEFL) is located on the short arm of chromosome 8.
These patients were negative for pathogenic variants of PMP22, MFN2, MPZ, GJB1, GDAP1, HSPB1, HSPB8, EGR2,
NEFL , and RAB7 .
Moreover, C3-knockout mice demonstrated higher expression levels of genes involved in maintaining the physiological function of the neural retina: abhydrolase domain containing 14A (Abhd14a); complexin 4 (Cplx4); cGMP specific-phosphodiesterase 6C (Pde6c); neurofilament (
Nefl); aldehyde dehydrogenase family 1, subfamily A1 (Aldh1a1); retinitis pigmentosa GTPase regulator interacting protein-1 (Rpgrip1); and regulator of G protein signaling 9 binding protein (Rgs9bp).
NC = North Carolina; SC = South Carolina SEFL = southeast Florida;
NEFL = northeast Florida.
NEFL, Wistar rats, FTH1, TUFM, PEA15, and also PEBP, PFN1, CCT2, treated with IDH3A, COX5A, COX5B, the anti- PRDX2 Parkinson drug; rasagiline or the anti- Alzheimer's disease drug; ladostigil cerebellum from Fisher 344- Brown Norway rats from 5-, 22-and 34- month-old rats Ryr3, Lrp2, Nrap, [95] Cnp Brain Brain from male Decreased: PK, [48] Wistar rats ATP5al, ALDOC, CKB, from 12 to 28 a-enolase.
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