Although congenital nevi
, deep penetrating nevi
, cellular blue nevi
, and some Spitz nevi
may extend deeply into the dermis, lesions that extend deeply but do not fall into any of these categories should be viewed with some suspicion.
(1) FGFR3 and PIK3CA mutations are associated with 50% of keratinocytic nevi
. Of the RAS family, the HRAS pathway has been most closely associated with nevus sebaceous.
About half had a history of dysplastic nevi
, and a third had a history of melanoma.
Nevus sebaceous of Jadassohn or verrucous epidermal nevi
, is a hamartomatous lesion expressing elements of sebaceous and apocrine glands, defective hair follicles, acanthosis and papillomatosis.
Most EAC nevi
can be excised via a transcanal or transmeatal approach under microscopy, but larger lesions should be excised by endaural incision.
Khalifa, "Blue nevi
of the Mullerian tract: case series and review of the literature," Journal of Lower Genital Tract Disease, vol.
HN patients with two or more involved nevi
, KP, or familial background of vitiligo may carry an increased risk of developing vitiligo.
The evaluation of choroidal nevi
can be a diagnostic challenge because in some cases a distinction between a benign nevus and a small choroidal melanoma is not readily apparent .
Independent of the matter, pigmented lesions, unique and multiple, often with no associated subjective symptoms (for example: pigmentary nevi
), are able to raise some concerns in certain patients.
Congenital melanocytic nevi
(CMN) are pigmented lesions that are present at birth and created by the abnormal migration of neural crest cells during embryogenesis.
Medically, pigmented moles are called Naevi or Nevi
, so a Melanocytic Naevi is a common benign mole of which most human beings have varying numbers.