NF-1


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AcronymDefinition
NF-1Neurofibromatosis Type 1
References in periodicals archive ?
In classical NF-1, skeletal defects occur as a result of abnormalities of the neuroectoderm and mesoderm.
(6) Spine, long bones, and craniofacial bones are the main localizations of NF-1. Involvement of the spine includes scoliosis.
NF-1 is characterized by cutaneous and plexiform neurofibromas, skin pigmentation (axillary and inguinal freckling, cafe-au-lait spots), Lisch nodules, optic glioma or skeletal dysplasias [4, 5].
Cardiovascular effects are relatively common in patients with NF-1 due to coartation of the aorta, renal artery stenosis or PHEO [6].
Orthopaedic disorders such as sphenoid dysplasia, thinning of the cortex on the long bones, demineralization, scoliosis, hypotonia and poor coordination are very common in patients with NF-1. People affected by NF-1 also have cognitive delay, learning disabilities and attention deficits.
First bloom date and plant height were highly variable among and within the parental accessions comprising NF-1. Averaged across 2 yr, date of first bloom ranged from 158 to 180 d and plant height ranged from 171 to 195 cm among the parental accessions.
When they are not associated with NF-1, they are usually solitary.
Although our patient's circumstances did not satisfy the strict criteria for plexiform neurofibroma, our index of suspicion remained high for NF-1 given the presence of multiple nodules and their atypical location.