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NF2 staining was detected in all cases of benign mesothelial proliferations, and loss was identified in only a single mesothelioma (1 of 25, 4%) (Table).
Hippo Pathway.--Merlin, the protein encoded by NF2, regulates cell growth by signaling via the Hippo pathway to inhibit the function of the transcriptional coactivator and candidate oncogene YAP1 via its phosphorylation.
Soft tissue perineurioma in a patient with neurofibromatosis type 2: a tumor not previously associated with the NF2 syndrome.
(6,7) The microsatellite markers analyzed were associated with tumor suppressor genes including CMM, MYCL, VHL, APC, MCC, CDKN2A, PTEN, MXI1, TP53, and NF2. Polymerase chain reaction amplification was designed to generate an amplicon less than 200 base pairs long using synthetic oligonucleotide primers flanking each microsatellite.
In this study, we aimed to assess the utility of MTAP immunohistochemistry as a first-line approach to distinguishing malignant epithelioid mesothelioma from benign reactive mesothelial proliferations, and to compare the results to those obtained with the established markers of BAP1 immunohistochemistry, and CDKN2A and NF2 FISH.
Frequency of loss of heterozygosity of the NF2 gene in schwannomas from Croatian patients.
Neurofibromatosis type 2 (NF2) is one of the three kind of Neurofibromatosis (NF), a rare disorder that affects one in every 33,000 people around the world--including myself.
In this context, monosomy 22 and neurofibromatosis type 2 (NF2) diseases, harbouring inactivating mutations of NF2 gene, have been the first genetic anomalies correlated to meningiomas development [4].
A logical circuit of Host Scan (HS) analysis uses four primary inputs NF1, NF2, LF_PING, LF_IDLE_SCAN and produces a primary output labelled as HS.