NFKBIA


Also found in: Medical.
AcronymDefinition
NFKBIANuclear Factor of Kappa Light Chain Gene Enhancer in B Cells Inhibitor, Alpha
References in periodicals archive ?
10 NF-B1 and IBa are encoded by the NFKB1 and NFKBIA genes respectively, and it has been shown that disrupted expressions of these genes can result in carcinogenesis.
To test our hypothesis, we conducted a case-control study to investigate the association of NFKB1 -94 ins/del ATTG polymorphism and NFKBIA -826C>T and -881A>G polymorphisms with the risk of lung cancer in a Chinese population.
Association of NFKB1 and NFKBIA polymorphisms with lung cancer risk: The association between NFKB1 and NFKBIA polymorphisms and lung cancer risk is shown in Table-I.
Table-I: Association between NFKB1 -94 ins/del ATTG polymorphism, NFKBIA -826C>Tpolymorphism and NFKBIA -881A>G polymorphism and lung cancer risk.
Table-II: Association between combinations of NFKB1 -94 ins/del ATTG polymorphism and NFKBIA -826C>T polymorphism and lung cancer risk.
Table-III: Association between combinations of NFKB1 -94 ins/del ATTG polymorphism and NFKBIA -881A>G polymorphism and lung cancer risk.
Moreover, the authors learned, patients with either the NFKBIA or EGFR abnormality had a significantly shorter survival, despite maximal therapy, than the remaining patients whose tumors bore neither genetic defect.
The defects on NFKBIA and EGFR have a similar effect on an important molecule called NF-kappa-B, a "transcription factor" found in all cells, but they do this by different mechanisms.