NIBUTNon Invasive Break Up Time (measurement used in dry eye treatment)
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Currently, Tearscope is the only commercially available instrument for measuring tear film lipid layer thickness, as well as NIBUT (21).
As it produces the same type of light as Tearscope, it can measure lipid layer thickness and NIBUT in the same way as Tearscope, as is explained in more detail in the Methods section, and it therefore might enable NIBUT measurement to become part of everyday clinical practice.
(6) NIBUT values of 10 seconds or less were included in the dry eye group.
The groups were similar in age and gender distribution, while meibomian gland loss was higher and NIBUT was lower in the dry eye group compared to healthy controls (Table 1).
NIBUT was assessed with a dry eye testing device (Oculus Keratograph, Germany).
However, no significant differences in NIBUT and FLCS were observed during the same period (NIBUT, week 0: 14.79 [+ or -] 5.43 s versus week 4: 14.77 [+ or -] 5.41 s; FLCS, week 0: 0.29 [+ or -] 0.62 versus week 4: 0.21 [+ or -] 0.41; p > 0.05).
Positively skewed raw NIBUT data were logarithmically transformed prior to parametric statistical testing.
The NIBUT is the amount of time (in seconds) that passes between your last complete blink and the instant you experience ocular discomfort.
For NIBUT measurement, the subjects were instructed to blink two times and then keep their eyes open to the best of their ability.
The distribution of NIBUT values was normal (KolmogorovSmirnov test, p>0.05 on all occasions), and therefore parametric tests were applied (ANOVA with post hoc analysis and Pearson's correlation coefficient).
This is called the non-invasive break-up time (NIBUT).