Our initial analysis was limited to those chemicals with both positive (active) [ACC.sub.ER] values in the ToxCast[TM] ER model and at least two positive (guideline-like) uterotrophic studies from the NICEATM
uterotrophic database (Kleinstreuer et al.
. Center for the Evaluation of Alternative Toxicological Methods.2003.Test Method Protocol for Solubility Determination.
We developed ICE to address needs that have been expressed frequently by NICEATM
To address the need for standardized and validated protocols, in 2015 staff from NTP and NICEATM
initiated the Systematic Evaluation of the Application of Zebrafish in Toxicology (SEAZIT) to gather the information and data required to achieve a higher degree of standardization for zebrafish embryo protocols.
conducted a comprehensive literature search to identify uterotrophic studies for environmental chemicals.
The Act also prescribed specific duties intended to facilitate review and acceptance of test methods, established an external scientific advisory committee, and required the director of the NIEHS to establish ICCVAM under the National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM
), which currently exists as a functional unit within the Division of the NTP at the NIEHS.
Nicole Kleinstreuer, the deputy director of the Interagency Center for the Evaluation of Alternative Toxicological Methods of the National Toxicology Program (NICEATM
), began the next talk on improving read-across using biological data and quality assessment by stating that it is important from a scientific standpoint to ultimately achieve regulatory acceptance in the US.
is co-organizing a workshop on September 18-19 with the PETA
In November 2011 the National Institute of Environmental Health Sciences and the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM
) issued a request for comments to be considered by NICEATM
and the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) in updating the current NICEATM/ICCVAM 5-year plan to cover the years 2013-2017.
The international community recognized a need to expand this to MPS and stem cell-based models ten years later, and under the lead of CAAT, with participation of FDA, NIH NCATS, NICEATM
, ECVAM, UK Stem Cell Bank and others, GCCP 2.0 was initiated.
1995) and is currently undergoing validation for international use by ICCVAM/NTP (National Toxicology Program) Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM
The Cosmetics Europe Skin Tolerance Task Force and the National Toxicology Program Interagency Center for Evaluation of Alternative Toxicological Methods (NICEATM
) have evaluated several of these DAs using a comprehensive database with non-animal test method, LLNA and human skin sensitization data (Hoffmann et al., 2018; Kleinstreuer et al., 2018).