The NLCR was calculated using neutrophil and lymphocyte levels.
Statistical analysis was performed to determine the value of the NLCR and other infection markers for predicting bacteremia between study and control groups.
The significance of NLCR, neopterin and pro-ADM levels on predicting bacteremia was evaluated by receiver operating characteristic (ROC) curve analysis.
Table-II: Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of the NLCR, neopterin and pro-ADM in predicting bacteremia.
Mean CRP levels and NLCR were similar between both groups (p=0.343, p=0.337) (Table-I).
ROC analysis demonstrated that neopterin and pro-ADM had the highest area under the curve (AUC) compared to NLCR for predicting bacteremia in ICU.
The median survival time was 11 days in all patients, 17 days in bacteremic patients and eight days in non-bacteremic patients, 14 days in medical patients and six days in surgery patients, 11 days in patients with NLCR value 39.
In our study, NLCR, neopterin, pro-ADM and the other infection markers was investigated in septic patients as predictors of bacteremia.
Therefore, NLCR increases in infectious diseases and have turned into inflammatory markers.
Gurol and colleagues demonstrated that optimal NLCR cut-off value should be more than five for identifying sepsis due to effects of surgery, trauma and rheumatic disease.19,20 In our study we found the higher cut-off value than the other studies.
Although shown the prognostic significance of NLCR was demonstrated in a study that included 2,311 patients, the prognostic value was not demonstrated in another study of 5056 patients analyzed.25 Only procalcitonin was found to be significant among the examined markers in predicting mortality in our study.