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A small number of IGRA positive tests in healthy Controls and NMLD patients did not allow for proper calculation of the association between these two immunological parameters.
Finally, we found no correlation between the expression of membrane bound mCD14 and serum concentration of soluble sCD14 molecules in the study groups: TB patients (r = 0.26, P = 0.09), TB contacts (r = 0.22, P = 0.11), Controls with no known TB contact (r = 0.15, P = 0.30), and NMLD patients (r = 0.21, P = 0.18).
Also, there were no intergroup differences in TLR2 MFI values in CD14(+) monocytes (Figure 7(b), right) from TB and NMLD patients and healthy participants with or without contacts to infectious TB, both IGRA negative and positive participants (Figure 7(c), right).
Also, the CD206 MFI values observed in TB and NMLD patients and healthy volunteers with or without contacts to infectious TB were similar (Figure 8(b), right), in both IGRA negative and positive (Figure 8(c), right) participants.
The analysis of flow cytometry data for LFA-1 integrin revealed that healthy Controls with no known TB contact possessed significantly higher proportion of LFA-1 positive monocytes as compared to TB and NMLD patients and work contacts of TB patients, although in household contacts only a trend to increase was noticed (Figure 9(b), left).
The decreased frequency of monocytes with mCD14 and LFA-1 coexpression in PBML from TB and NMLD patients could have been caused by intensive recruitment of such cells into lungs.
It is quite likely that endothelial cells could have been a source of sCD14 increase in NMLD patients developing an inflammatory response to bacterial infections.
However, we could see no difference in the TLR2 expression on monocytes from TB or NMLD patients and healthy volunteers with or without contacts to infectious TB.
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