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No IMP3 staining was observed in any of the NNEM and BM uninvolved by dysplasia (Figure 1, A and B).
IMP3 was more frequently expressed in EAC compared with ECD, BM, and NNEM (P < .001).
All 14 cases containing NNEM, including squamous epithelium, metaplastic columnar epithelium without goblet cells, and submucosal esophageal glands, showed no staining for IMP3.
In this study, we found that IMP3 is overexpressed in EAC and a subset of ECD but not in BM and NNEM. Low-grade ECD is noted to have only focal weak IMP3 expression in contrast to high-grade ECD, which showed more intense diffuse expression of IMP3.
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