The relative risk of comorbid breast cancer is 1.25, compared with an attributable risk of 6.23 per 10,000 patient-years and an NNH
of 1,606, Mr.
Rates of discontinuation because of an adverse event were not higher for active medication vs placebo for the schizophrenia studies, suggesting excellent overall tolerability, and for MDD the NNH
vs placebo on discontinuation because of an adverse event was 50, representing reasonable overall tolerability for this indication as well (Table 1, (1) page 27).
active comparators (RR, 2.70; 95% CI, 1.25-5.83; NNH
, 11), although the quality of evidence was very low.
The nearest-neighbor heuristic (NNH
) starts each route by finding the unvisited customer nearest to the depot.
(number needed to harm), however, is usually 1 or close to it.
Also, the company stated that under a securities purchase agreement signed on 28 March 2016, it issued and sold 10,000,000 shares of its common stock to 200 NNH
at USD0.12 per share, subject to an 18-month lock-up period.
However, the NNH
of 29 for valproic acid seen in the new study shows this drug is problematic, too.
The most common side effects of duloxetine - nausea, fatigue and constipation - were small when compared to the placebo, resulting in NNHs
of 16, 17 and 19 respectively.
For example, Saphris dosed at 20 mg per day yields an NNH
of 13 for the side effect akathisia (restlessness).
Information about the NNH
is often available in the package insert.
By using the odds ratio from the metaanalysis, the investigators calculated the number needed to harm (NNH
) according to varying risk factors such as ulcer drug use and hospitalization for any upper GI event.