NOAECNo Observed Adverse Effect Concentration
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The NOAEC of 10 of the IPs had been determined in the mouse bioassay previously (see Tab.
It is however not possible to use the in vitro ranking to predict the NOAEC exposure concentration in vivo.
The dose-response toxicity data allowed for three doses to be chosen for the hsp70 expression studies: 0.2 [micro]M (low dose) was the NOAEC over the 96-hr exposure, 5 [micro]M (middle dose) was near the E[C.sub.50], and 125 [micro]M (high dose) caused 100% mortality during the acute test.