NOD1Nucleotide Oligomerization Domain 1
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Identification of polymorphisms: Genomic sequences containing the caprine NOD1 and NLRP9 genes were used to detect SNP in these genes, and primers were designed using the NCBI Primer-BLAST web Program ( from the CDS of the NOD1 and NLRP9 genes (NCBI, Gen Bank association number: NW_017189490 and NW_017189504 respectively).
The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll like receptor ligands.
We then screened CBT targeted pathway by quantitative real-time polymerase chain reaction (qPCR) array and enrichment analysis, which was further confirmed using NOD1 selective inhibitor ML130.
Abbreviations APAF-1: Apoptotic protease-activating factor-1 BBB: Blood-brain barrier BWC: Brain water content CARD: Caspase-associated recruitment domain CSF: Cerebrospinal fluid EB: Evans blue GM-di: GlcNAc-MurNAc dipeptide [GM-Tri.sub.lys]: GlcNAc-MurNAc tripeptide muropeptide IHC: Immunohistochemistry IL: Interleukin IL-1[beta]: Interleukin-1 beta IL-6: Interleukin-6 MDP: Muramyldipeptide NOD1: Nucleotide-binding oligomerization domain 1 NOD2: Nucleotide-binding oligomerization domain 2 OD: Optical density PRR: Pattern-recognition receptors qRT- Quantitative real-time polymerase chain PCR: reaction R-protein: Disease-resistance proteins TNF: Tumor necrosis factor TNF-[alpha]: Tumor necrosis factor-alpha.
NOD1 is structurally similar to other NLR proteins in that it is composed of an N-terminal caspase activation and recruitment domain (CARD), a central NOD and a C-terminal leucine-rich repeat domain (LRR).
In addition, the expression of NOD1 was suppressed in both C57BL/6J mice fed the WD and db/db mice (Figures 5(c) and 5(d)).
Philpott, "Resilience of the intestinal microbiota following pathogenic bacterial infection is independent of innate immunity mediated by NOD1 or NOD2," Microbes and Infection, vol.
Cardell, "Innate immune receptors in human airway smooth muscle cells: activation by TLR1/2, TLR3, TLR4, TLR7 and NOD1 agonists," PLoS ONE, vol.
McMasteret al., "Selective NOD1 agonists cause shock and organ injury/dysfunction in vivo," The American Journal of Respiratory and Critical Care Medicine, vol.
Matsuo, "Roles of TLR2, TLR4, NOD2, and NOD1 in pulp fibroblasts," Journal of Dental Research, vol.