Both NPWE and NPDP showed inhibitory activity on [alpha]-glucosidase and are expected to prevent radical increase of blood glucose levels as decomposition into monosaccharide by [alpha]-glucosidase in the small intestine.
This study also verified the function of NPWE as a hypoglycemic agent by confirming the inhibitory activity of NPWE on [alpha]-glucosidase.
Effects of NPDP and NPWE on Glucose Tolerance in the Fed a High-Fat Diet Rats.
Effect of NPWE on Glucose Tolerance in the STZ-Induced Diabetic Rats Fed a High-Fat Diet.
The results of the [alpha]-glucosidase inhibition activity experiment showed that NPWE had a slightly lower level of inhibitory activity, with an [IC.sub.50] of 67.33 [micro]g/mL, than the comparison medicine acarbose.
Moreover, administration of medication and NPWE tends to reduce activity of AST (16.8%), ALT (27.0%), and cholesterol (24.4%) more than the HF-STZ-Control group (Table 3).
We fed animals with a high-fat diet that might cause prediabetes condition in humans supplemented with NPWE, allowing us to calculate intake of dietary fiber from food intake.
In conclusion, the study demonstrates that NPWE significantly improves deranged carbohydrate metabolism in STZ-induced diabetic rats fed a high-fat diet.
Caption: Figure 1: Single-term oral glucose tolerance tests (a) of Nopal dry powder (NPDP) and water extract (NPWE) after 12 h food deprivation in SD rats fed a high-fat diet.
Caption: Figure 2: Long-term oral glucose tolerance tests (a) of Nopal water extract (NPWE) after 12 h food deprivation in STZ-induced SD rats fed a high-fat diet.