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NRAMPNatural Resistance Associated Macrophage Protein
NRAMPNevada Risk Assessment/Management Program
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As mentioned earlier, Nramp is another novel family of related proteins that are playing an important role in transport of divalent metal ions.
NRAMP was described as the gene involved in resistance/susceptibility to intracellular pathogens in mice where a single coding SNP was responsible for susceptibility in Balb/C.
In particular, vertebrate phagocytes have displayed natural resistance-associated macrophage protein (nramp) activity that transports metal ions for defensive purposes (Alkinson & Barton 1998, Jabado et al.
bovis BCG infection is controlled by a single dominant gene designated Nramp (natural resistance-associated protein macrophage protein) which regulates the initial activation of macrophages for NO production (Vidal et al., 1993; Brown et al., 1995).
The Nramp (Bcg/Lsh/Ity) gene was originally identified in inbred strains of mice and shown to confer increased susceptibility to infection by several infectious agents (30-32).
In turn, the RNAi technology has yielded significant insights into virus-host interactions, such as the identification of the ion transporter NRAMP as the receptor for the mosquito-borne Sindbis virus colonization of Drosophila cells [41].
Although there is no direct evidence for a role of plasma membrane efflux transporters in the HM tolerance in plants, recent research has revealed that plants possess several classes of metal transporters such as heavy metal (or CPX-type) ATPases that are involved in the overall metal-ion homeostasis and tolerance in plants (Williams et al., 2000), the natural resistance-associated macrophage-protein (Nramp) family, cation-diffusion facilitator (CDF) proteins family and the zinc-iron permease (ZIP) family (Guerinot, 2000).
Structure of the bovine natural resistance associated macrophage protein (NRAMP 1) gene and identification of a novel polymorphism DNA Seq.
Nramp 1 is part of an ancient family of proteins with highly conserved members in mammals (including humans, cows, rats, sheep), birds, invertebrates (C.