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Zhang et al., "NRAMP1, VDR, HLA-DRB1, and HLA-DQB1 gene polymorphisms in susceptibility to tuberculosis among the Chinese Kazakh population: a case-control study," BioMed Research International, vol.
The NRAMP1 protein has 12 conserved transmembrane domains, two N-linked glycosylation sites, and a transport motif.
Polymorphisms of the human NRAMP1 gene are associated with response to bacillus Calmette-Guerin immunotherapy for superficial bladder cancer.
Natural resistance to intracellular infections: natural resistance-associated macrophage protein 1 (nramp1) functions as a pH-dependent manganese transporter at the phagosomal membrane.
We investigated several polymorphic loci within the tumor necrosis factor-[alpha] (TNF[alpha]), interleukin-4 (IL-4) receptor, and NRAMP1 genes, all of which may play important roles in the outcomes of infections of various types.
The Nramp2 gene resembles another gene, Nramp1, whose protein plays a crucial role in animals' resistance to bacteria that invade their cells.
BALB/c or C57BL/6 mice have a mutation in the gene formerly known as Nramp1 (natural resistance-associated macrophage protein one) and renamed the Slc11a1 gene that leaves them susceptible to systemic infection by S.
Peters et al., "Slc11a1 (Nramp1) alleles interact with acute inflammation loci to modulate wound-healing traits in mice," Mammalian Genome, vol.
Solute linked carrier 11A1 (SLC11A1), a transmembrane protein (also referred as Natural Resistance Associated Macrophage Protein 1, NRAMP1), is one of the potential candidate genes that confer innate resistance against various intracellular pathogens.
Case control studies have found significant associations between tuberculosis and gene polymorphisms like human leukocyte antigen (HLA) (2) and non-HLA genes such as natural resistance associated macrophage protein (NRAMP1) (3), vitamin D receptor (VDR) (4), mannose binding lectin (MBL) (5), interleukin-1 (IL-1) (6), IL-10 (7) and IL-12 receptor (8).
Also genetic factors (32), for example the presence of polymorphism of the NRAMP1 gene (33,34) may contribute to differences in the susceptibility to acquire extrapulmonary TB.
The SLC11A1 protein, also known as NRAMP1 (natural resistance-associated macrophage protein-1) is located at 2q35 and has a role in ion transportation.
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