NRAMP2Natural Resistance-Associated Macrophage Protein 2
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Su et al., "Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene," Nature Genetics, vol.
Characterization of chicken natural resistance-associated macrophage protein encoding genes (Nramp1 and Nramp2) and association with salmonellosis resistance.
Divalent metals Fe, Cu, Ag, and zinc (DMT1, DCT1, and Nramp2) transports, ferroprotein, Divalent metals Fe3+ and cobalt Divalent metal transporter (Co2+), Ca++, Fe++, 1, divalent cation Mn++, Cd++, Cu++, transporter 1 (DCT1) Ni++, Pb++, Zn ++ Trivalent metals Al and Mn Diferric transferrin Methyl mercury Transport by the L-cysteine system Element Functions References Molybdenum Cofactor or activator of certain enzymes (e.g., nitrogen fixation, nucleic acid metabolism, and aldehyde oxidation) Cobalt Constituent of vitamins [B.sub.12] Copper Constituent of plastocyanin and [28-32] cofactor of respiratory enzymes.
DMT-1 Also known as DCT1, Nramp2, BMP identified as homologue of Nramp1, a protein that confers resistance to intracellular pathogens.
[5] Human genes: HFE, hemochromatosis; HJV (alias, HFE2), hemochromatosis type 2 (juvenile); HAMP, hepcidin antimicrobial peptide (alias, LEAP-1); SMAD4, mothers against DPP homolog 4 (Drosophila); TfR2, transferrin receptor 2 (alias, HFE3); SLC40AI, solute carrier family 40 (iron-regulated transporter), member 1 (aliases, IREG1, FPN1, HFE4); FTL, L-ferritin; and SLCIIA2, solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 (aliases, DMT1, DCT1, and NRAMP2).
That gene was Nramp2. Hediger's team also found that Nramp2 helps the eggs absorb other metals, such as copper, zinc, and cadmium.
The Nramp2 gene resembles another gene, Nramp1, whose protein plays a crucial role in animals' resistance to bacteria that invade their cells.
Functional complementation of the yeast divalent cation transporter family SMF by NRAMP2, a member of the mammalian natural resistance-associated macrophage protein family.
Microcytic anemia mice have a mutation in Nramp2, a candidate iron transporter gene.
DMT1 (9), previously called Nramp2 (6,10-13) or DCT1 (7), is a duodenal metal transporter with affinity for several divalent cations.
Reciprocal regulation of HFE and Nramp2 gene expression by iron in human intestinal cells.