References in periodicals archive ?
Gene mapping and positive identification of the non-structural proteins NS2A, NS2B, NS3, NS4B and NS5 of the flavivirus Kunjin and their cleavage sites.
NS2 and NS4 can be further processed into two mature NS (NS2A and NS2B and NS4A and NS4B), in which NS2 may be a major factor that leads to CPE [14].
NS4A is involved to form the complex with the viral proteins such as NS3, NS4B and NS5A.
(51-53) The 4 small nonstructural proteins NS2A, NS2B, NS4A, and NS4B are associated with intracellular membranes, where they are involved in inducing membrane alterations, assembling the viral replication complex, and evasion of innate immune path ways.
The nonstructural proteins (NS1, NS2a, NS2b, NS3, NS4a, NS4b, and NS5) are responsible for the viral replication, assembly, and immune response escape [8].
The genome is translated into a single polyprotein and subsequently cleaved by viral and host proteases into three structural proteins (C, prM/M, and E) and seven nonstructural (NS) proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B, and NS5) [9,11].
Joy and his associates studied 45,316 HCV genotype la sequences from the National Center for Biotechnology Information GenBank nucleotide database to carry out phylogenetic analyses of five HCV genes--E1, E2, NS2, NS4B, and NS5B (Lancet Infect Dis.
The genome encodes 7 non-structural proteins significant for virus replication in infected cell: NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5.
HCV is an enveloped positivesingle stranded RNA virus whose genome encodes a single polyprotein that produces mature proteins in the host cell: mature viral structural proteins (Core, E1, E2, and possibly p7) and nonstructural proteins (NS2, NS3, NS4A, NS4B, NS5A, and NS5B) [181].