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While Mitrofanova and collaborators are researching a potential drug to target NSD2, she encourages doctors to begin incorporating NSD2 screening so they can start high-risk patients on anti-metastatic treatment as soon as possible.
NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming.
Boston, MA, May 16, 2014 --(PR.com)-- Ho Man Chan at Novartis will give a presentation on “Global Chromatin Profiling Leads to the Identification of NSD2 Mutations in Pediatric Acute Lymphoblastic Leukemia” at the 5th Cancer Targets & Therapeutics Conference to be held on July 7-8, 2014, in Boston, MA.
Because depth was important and we desired a panel no larger than 1 Mb, several large genes previously shown mutated i cancer but with no direct clinical implications were not included, such as titin (TTN),  Wolf-Hirschhorn syndrome candidate 1 (WGHSC1, also known as NSD2), and microtubule-actin crosslinking factor 1 (MACF1).
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