This study, which directly compared the 2 commercially available hs-cTn assays (Roche hs-cTnT and Abbott hs-cTnI) in NSTE-ACS
patients, revealed novel and complementary findings on the following topics: (a) prediction of significant coronary lesions, (b) long-term prognosis during a mean follow-up of more than 8 years, and (c) thorough analyses of the relationship and dispersion between different cTn methods.
Relationship between elevated MPV and NSTE-ACS
has already been demonstrated in previous studies (2, 3).
However, the ideal score for risk stratification on admission for NSTE-ACS
should have a good balance between complexity and utility.
In this substudy of the Platelet Inhibition and Patient Outcomes (PLATO) trial, we therefore investigated if measurements of these new biomarkers and the angiographic information on extent of CAD might improve prognostication of different outcomes in patients with NSTE-ACS
managed with early revascularization.
Methods: This is a retrospective observational study; evaluating the MPV values of 79 NSTE-ACS
patients aged under 45 years and 45 control subjects having normal coronary anatomy.
This finding constitutes a compelling argument for a change in the existing ACC/American Heart Association guidelines, which recommend a routine invasive strategy in NSTE-ACS
patients with high-risk indicators, but state that in moderate- or low-risk patients the routine invasive or selective invasive approach is appropriate, said Dr.
The independent association of GDF-15 with mortality was later confirmed in other patient populations presenting with NSTE-ACS
or ST-elevation MI (STEMI) (42, 43).
Heart-type fatty-acid binding protein (H-FABP) is a new diagnostic marker of myocyte injury for the early diagnosis (within 2h after symptom onset) of ST elevation MI (14) and NSTE-ACS
For this study, we pooled individual patient-level clinical and biomarker data from 2 trials of patients with NSTE-ACS
Similarly, in TACTICS-TIMI (Treat Angina With Aggrastat and Determine the Cost of Therapy With an Invasive or Conservative Strategy Thrombolysis in Myocardial Infarction) 18, the prognostic value of cardiac troponin after NSTE-ACS
was broadly equivalent in men and women, although the marker appeared to be a stronger predictor of recurrent MI in women than men (17), a finding supported by a second independent analysis (18).