NSTE-ACSNon-ST-Segment Elevation Acute Coronary Syndrome (describes EKG in a type of unstable angina or heart attack)
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This study, which directly compared the 2 commercially available hs-cTn assays (Roche hs-cTnT and Abbott hs-cTnI) in NSTE-ACS patients, revealed novel and complementary findings on the following topics: (a) prediction of significant coronary lesions, (b) long-term prognosis during a mean follow-up of more than 8 years, and (c) thorough analyses of the relationship and dispersion between different cTn methods.
Relationship between elevated MPV and NSTE-ACS has already been demonstrated in previous studies (2, 3).
However, the ideal score for risk stratification on admission for NSTE-ACS should have a good balance between complexity and utility.
In this substudy of the Platelet Inhibition and Patient Outcomes (PLATO) trial, we therefore investigated if measurements of these new biomarkers and the angiographic information on extent of CAD might improve prognostication of different outcomes in patients with NSTE-ACS managed with early revascularization.
This finding constitutes a compelling argument for a change in the existing ACC/American Heart Association guidelines, which recommend a routine invasive strategy in NSTE-ACS patients with high-risk indicators, but state that in moderate- or low-risk patients the routine invasive or selective invasive approach is appropriate, said Dr.
The independent association of GDF-15 with mortality was later confirmed in other patient populations presenting with NSTE-ACS or ST-elevation MI (STEMI) (42, 43).
For this study, we pooled individual patient-level clinical and biomarker data from 2 trials of patients with NSTE-ACS (14, 15).
Similarly, in TACTICS-TIMI (Treat Angina With Aggrastat and Determine the Cost of Therapy With an Invasive or Conservative Strategy Thrombolysis in Myocardial Infarction) 18, the prognostic value of cardiac troponin after NSTE-ACS was broadly equivalent in men and women, although the marker appeared to be a stronger predictor of recurrent MI in women than men (17), a finding supported by a second independent analysis (18).