In order to solve this controversy, the MADIT-II (7) trial, published in 2002, expanded the study population to include patients with a myocardial infarction more than 30 days prior to enrollment and a LVEF of 30% or less, with or without evidence of presence of NSVT.
In this study, 458 patients with nonischemic dilated cardiomyopathy, LVEF less than 36%, and premature ventricular complexes or NSVT were randomly assigned to receive standard medical therapy only versus standard therapy plus ICD.
Landmark Clinical Trials on ICD Therapy for Primary Prevention of SCD Year Study Patient Characteristics Results 1996 MADIT Ischemic cardiomyopathy, Mortality decreased from LVEF <35%, NYHA class I, 39% in non-ICD group to II, or III, documented 16% in ICD group NSVT or inducible VT on invasive testing 1999 MUSTT Ischemic cardiomyopathy, Mortality decreased from LVEF < 40%, asymptomatic 55% in non-ICD group to NSVT 24% in ICD group 2002 MADIT-II Ischemic cardiomyopathy, Mortality decreased from LVEF < 30%, myocardial 19.
A clinical study conducted in 325 consecutive infarct survivors aimed to investigate the role of NSVT and other variables detected with 24-h Holter monitoring 10 days after myocardial infarction.
As mentioned above, although one large observational study identified NSVT and complex arrhythmias as predictors of SCD in patients with myocardial infarction, it is still controversial whether NSVT might be regarded as an independent predictor for SCD in coronary heart disease.
Each patient was placed on a Holter monitor for 24-hour time domain monitoring and 34% were found to have NSVT.
The heart rate variability parameters of patients with NSVT were significantly worse.
A higher percentage of LBBB and higher numbers of PVC and NSVT were also observed.
Indeed, in our study, the incidence of ventricular ectopic rhythm, including PVC and NSVT on ambulatory monitoring, was higher in IDCM patients with wide QRS-T angles, as were total mortality and cardiac mortality.
report a case of left bundle branch block NSVT morphology in a 33-year-old man who presented with palpations for 2 weeks .
2007  -- 24 months NSVT only (4) Horduna et al.
Approximately 15-20% of adult patients with HCM demonstrate NSVT
(defined as a run of three or more ventricular beats at a rate of at least 120 bpm) during 48 hour ambulatory ECG recording (6,11,22,23).