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We next asked if ntMSCs could exert cytoprotective effects on cardiomyocytes in the setting of oxidative stress, as this type of injury is present in the setting of myocardial ischemia and heart failure [14, 15].
In light of these findings, we then asked if ntMSCs could mitigate the effects of severe myocardial ischemia in a rat model of myocardial infarction achieved by left anterior descending coronary artery ligation.
A distinguishing characteristic of ntMSCs is its higher expression and secretion of Shh as compared to bone-derived MSCs.
In the neonate with critical CHD undergoing cardiac surgery who is also at significant risk for developing heart failure later in life, the discarded thymus tissue is a practical and ample source of cardiac regenerative MSCs that can be expanded and cryopreserved, and thus ntMSCs warrant further evaluation for clinical translation.
Caption: Figure 1: (a) Subject-matched ntMSCs possess a higher Shh expression as compared to nbMSCs.
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- NTN bottleneck
- NTN Grid Scheme