NTRKNeurotrophic Tyrosine Kinase
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The program is tracking towards dual NDA submissions in NTRK tumour-agnostic and ROS1 NSCLC, if supported by clinical data, with an anticipated US commercial launch in both indications thereafter.
The company's lead molecule entrectinib is an orally bioavailable, CNS-active tyrosine kinase inhibitor being developed for tumours that harbor ROS1 or NTRK fusions.
Entrectinib targets tumours with one of two genetically defined gene rearrangements: ROS1 fusions in non-small cell lung cancer (NSCLC), and NTRK fusions across a broad range of solid tumours.
It was granted Breakthrough Therapy Designation by the US Food and Drug Administration (FDA) for the treatment of NTRK fusion-positive, locally advanced or metastatic solid tumours in adult and paediatric patients who have either progressed following prior therapies or who have no acceptable standard therapies, in May 2017.
Immunohistochemical expression of NTRK1 and NTRK2 has been shown in lung cancer, (4,10,12-14) but the expression profiles of these markers within lung carcinoma subtypes are unclear and the clinical utility of NTRK is unknown.
21) In this context, both NTRK1 and NTRK 2 exhibit comparatively high specificity but low sensitivity for squamous cell carcinoma, suggesting that they may be most effective in separating squamous cell carcinoma from adenocarcinoma as part of an immunohistochemical panel that includes other, more sensitive markers.
During early nervous system development, nascent neurons are dependent on neurotrophin-induced signaling through NTRK receptors for survival, and limiting concentrations of neurotrophins ensure that an appropriate amount of neurons survive in a given situation and location.
M2 PHARMA-November 5, 2014-Enzymatics enhances Archer FusionPlex product line with targeted sequencing assays for NTRK, FGFR gene fusion detection
5 November 2014 - US reagents and kits developer Enzymatics Inc said Tuesday it had introduced two new targeted next generation sequencing (NGS) panels for detecting fusions in NTRK and FGFR gene families, based on Anchored Multiplex PCR (AMP), the company's NGS-based fusion detection technology.
The lots were drawn to appear at ElTR, NTRK, Radio Kabarlar, newspapers Slovo Kyrgyzstana,Erkin Too and Kyrgyz Tuusu.
The Human Rights Watch has refuted the statements made by Ombudsman of Kyrgyzstan Tursunbek Akun in an interview with the national television channel NTRK on August 17 that the HRW report on violence in Osh was based on 'one-sided' information provided by human rights defender Aziza Abdrasulova.
Shootout is taking place in the district called Geologicheskiy, reported NTRK correspondent.