NVRLNational Virus Reference Laboratory
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Hospitalizations in which a lumbar puncture (ICD-10AM code 39000-00) was listed were extracted from HIPE for comparison with the number of CSF samples received at NVRL for virologic testing and with those in which a virus was detected from patients with symptoms of acute encephalitis or meningitis.
NVRL does not routinely receive convalescent-phase serum samples; therefore, investigations of acute- or convalescent-phase serum are uncommon.
The NVRL received 6,502 CSF specimens collected during 2005-2008.
HAdVs were cultured at NVRL and Lovelace Respiratory Research Institute (Albuquerque, NM, USA).
We retrospectively tested clinical specimens received by NVRL from 29 patients with positive results for HAdV by IF, virus culture, or qPCR during the study period by using specific HAdV-11 and -14 real-time assays.
Dr Carr is a clinical scientist in the NVRL, University College Dublin, Ireland.