NF

(redirected from Neurofibromin)
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AcronymDefinition
NFNuclear Factor
NFNewfoundland
NFNorfolk Island
NFNiagara Falls (NY/Canada border)
NFNational Forest
NFNoise Figure
NFNetflix (also seen as NFLX)
NFNursing Facility
NFNon-Fiction
NFNavy Field (video game)
NFNational Front (GB political party)
NFNot Finished
NFNo Fear (clothing brand)
NFNear Fine (condition of used merchandise)
NFNeurofibromatosis
NFNo Fap (gaming community)
NFNut Free (food)
NFNo Fault (insurance)
NFNational Formulary
NFNot Fair
NFNew Frontier (Star Trek novel series)
NFNanofiltration
NFNormal Form
NFNew Front (Suriname)
NFNutrition Facts
NFNew Face
NFNear-Field
NFNuclear Fuel
NFNear Field
NFNecrotizing Fasciitis
NFNight Fighter (Aircraft)
NFNo Force (Star Wars)
NFNot Funny
NFNeurofibromatosis, Inc.
NFNeurofibromin
NFNear Face (screw thread)
NFNoise Factor
NFNanofarad
NFNetFinity (IBM server model)
NFNoise Filter
NFNatural Frequency
NFNorme Française (French Standard)
NFNotch Filter
NFNational Forum
NFNuestra Familia (Our Family, prison gang)
NFNeurofibromatosis Foundation (various locations)
NFNet Force (Tom Clancy novel series)
NFNational Fine (threading)
NFNanofiber
NFNumber of Failures
NFNear-Far (resistance)
NFNon-Factor
NFNOFORN
NFNaegleria Fowleri (amoeba)
NFNo Food
NFNeutral File
NFNeutron Flux
NFNational Fine (screw thread, Society of Automotive Engineers)
NFNo Funds
NFNorthumberland Fusiliers (British Army)
NFNormalizing Factor
NFNose Fuse (US Navy)
NFNormal Functionality
NFNarrow Frontend (tractor category)
NFNatural Fluorescence
NFNiteFinder (Nerf gun; Hasbro)
NFNasty Factor (baseball)
NFNose Fairing
NFNew Frontiers Program
NFNo Figure
NFNuclear Furnace
NFNowa Fantastyka (Polish)
NFNight Foreman
NFNintendo Forum
NFNordlands Framtid
NFNested Factorization (mathematics)
NFAir Vanuatu Limited (IATA airline code)
NFNegative Furnished
NFNordfinans
References in periodicals archive ?
These observations might tentatively be linked to peculiar aspects of the maturation and differentiation of Schwann cells in neurofibromas, which might translate into different concentrations of the cytoplasmatic content of neurofibromin, arising from differences in the morphological expression of genetic alterations of the NF1 gene (monoallelic or biallelic) [2-6] and the neural microenvironment [7].
Moreover, the protein sequence alignment showed a high degree of conservation of the amino acid sequence around the T2183 residue in the neurofibromin protein across 12 different species by the UCSC Genome Bioinformatics tool [Figure 1]e.
Neurofibromin is encoded by the NF1 tumor suppressor gene and functions as a negative regulator of p21Ras (Ras) activity in circulating hematopoietic and vascular wall cells [26, 100-103].
This condition is caused by inherited or de novo mutations of the NF1 gene at the 17q11.2 chromosomal region, a gene that codes for the protein neurofibromin [7].
MPNST tumor lines from human and mouse have been used to elucidate the mechanism of action of neurofibromin [40]; study the role of tyrosine kinase receptors [41-47], growth factors [48-50], p53 [51,52],micro-RNAs [30,53], and sex hormones [54-56] in MPNST biology; and examine the effects of chemotherapy [57-67] and viral therapy [68-71] as potential treatments for MPNST.
neurofibromatosis) with mutation of neurofibromin on chromosome 17q11.29,10.
Hegedus et al (30) showed that neurofibromin provides somatic growth by affecting the hypothalamic-pituitary axis.
The disease is caused by loss of function mutations in NF1 gene, a tumor suppressor on chromosome 17q11.2, that encodes neurofibromin. Neurofibromin is a guanosine triphosphatase-activating protein and a negative regulator of RAS proto-oncogene.
Tumors due to mutations of neurofibromin 1 (NF1) [4] and ret proto-oncogene (RET) genes show increases in metanephrine, usually with additional increases in normetanephrine (Fig.
(1,3) The pathophysiology is characterized by a mutation of the NF1 gene located on chromosome 17q11.2, responsible for secreting neurofibromin, a protein that inhibits abnormal cell growth.
Neurofibromin (the protein encoded by NF-1 gene) is an important element in the heart development and is expressed in both endothelial and smooth muscle cells of blood vessels [10].
The NF1 gene encodes a large cytoplasmic protein called neurofibromin, which is a major negative regulator of Ras protooncogene, a key protein in a major signal transduction pathway [50, 52].
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