TAC3/TACR3 mutations reveal preferential activation of gonadotropin-releasing hormone release by neurokinin
B in neonatal life followed by reversal in adulthood.
Luger, "Targeting the neurokinin
receptor 1 with aprepitant: A novel antipruritic strategy," PLoS ONE, vol.
Substance P binds to neurokinin
receptors (NK) in enteric cholinergic secretomotor neurons .
Henichart, Novel Potent Substance P and Neurokinin
A Receptor Antagonists.
TACs are a family of closely related peptides such as SP, neurokinin
A, and neurokinin
B, which act as neuropeptides in nonneuronal cells and noninnervated tissues .
[41-43] Furthermore, study found that stress-induced visceral hypersensitivity in female rats is estrogen-dependent and mediated through neurokinin
(NK1) receptor activation in the colon.
(("receptors, neurokinin-l"[MeSH Terms] OR ("receptors" [All Fields] AND "neurokinin-1 " [All Fields]) OR "neurokinin-l receptors" [All Fields] OR "neurokinin
1 receptor" [All Fields]) AND antagonist [All Fields]) AND ("ondansetron" [MeSH Terms] OR "ondansetron" [All Fields])
Finally, part three presents three case studies: T-type calcium channel and glycine transporter type 1 inhibitors, bioisosteric replacements for the neurokinin
1 receptor, and neuronal nitric oxide synthase inhibitors.
Mammalian tachykinins comprise a protein family including substance P (SP), neurokinin
A (NKA), neurokinin
B (NKB), and hemokinin-1 (HK-1).
Another study in patients with psoriasis showed that in noninvolved hairy skin of the arms and on the back chronic stress is associated with an increased number of inflammatory cells expressing neurokinin
1 receptor, most of them being mast cells .
Claesson, "Blockage of the neurokinin
1 receptor and capsaicin-induced ablation of the enteric afferent nerves protect SCID mice against T-cell-induced chronic colitis," Inflammatory Bowel Diseases, vol.
Hameed et al., "Increased expression of preprotachykinin-I and neurokinin
receptors in human breast cancer cells: implications for bone marrow metastasis," Proceedings of the National Academy of Sciences of the United States of America, vol.