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References in periodicals archive ?
Signatures of adaptive evolution within human non-coding sequence. Hum Mol Genet 2006; 15 : R170-5.
Genetic Technologies is an Australian biotechnology company that holds several United States and international patents in three leading areas of genetics: non-coding sequence/intron DNA analysis, non-coding sequence genomic mapping, and fetal cell recovery.
Genetic Technologies is a biotechnology company that holds several United States and international patents in three leading areas of genetics: non-coding sequence analysis, genomic mapping, and fetal cell recovery.
Genetic Technologies is an Australian biotechnology company that holds several US and international patents in three leading areas of genetics: non-coding sequence/intron DNA analysis, non-coding sequence genomic mapping, and fetal cell recovery.
Among the 43 significant SNPs identified in the study, there are 15 significant SNPs located in the protein coding sequences, while the others are mapped in the non-coding sequences. It is consistent with the previous studies that the clear majority of significantly associated SNPs reside outside the protein-coding regions, underscoring the important function of non-coding sequences in the genome [19].
The phenotype-genotype relationship observed in patients with coding versus non-coding mutations in PTF1A and PMM2 highlights the fundamental role of non-coding sequences in development of specific organs.
Therefore, there is a characteristic uneven distribution of the identified genetic variation- 83.3% of variable sites in the mGH gene were located within non-coding sequences, and only 16.7% within coding sequences; in the central region were 30.0% of the variable nucleotides, which constituted as many as 64.3% of the identified types of mGH gene structural variation (polymorphic/mutation sites).
They don't really know why genes contain the non-coding sequences, if those sequences do actually serve some subtle purpose or, whether the sequences do anything or not, they can give scientists useful information about how genes work.
A crucial conclusion from the debate on the biological significance of synonymous nucleotide variation, and not only in the context of the growth hormone gene in American mink, is the potential high importance of variation identified in non-coding sequences (Chamary and Hurst, 2004).
These genes are involved in a giant sea of various types of non-coding sequences which compose 98.6% of HG (misnamed popularly as "junk DNA").
[16,17] A two-fold approach was aimed at examining the critical region for both highly conserved coding and non-coding sequences as well as CNVs and to characterise these regions further to determine if they may be functional and play a role in the molecular aetiology of KWE.
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