Background factors of reflux esophagitis and non-erosive reflux disease
: a cross-sectional study of 10,837 subjects in Japan.
Tutuian et al., "Impedance-pH reflux patterns can differentiate non-erosive reflux disease
from functional heartburn patients," Journal of Gastroenterology, vol.
Minimal change esophagitis: prospective comparison of endoscopic and histological markers between patients with non-erosive reflux disease
and normal controls using magnifying endoscopy.
Cobiprostone is currently being developed for the treatment of non-erosive reflux disease
(NERD), a major subtype of gastroesophageal reflux disease (GERD).
"For example, some people have reflux of stomach materials other than acid, such as food, pancreatic juices, or bile; this condition is called non-erosive reflux disease
, or NERD.
However, refractory gastro-oesophageal reflux disease (GORD) symptoms, both typical and atypical (cough, chronic hoarseness, asthma and atypical chest pain), have become a substantial clinical problem that is most prevalent in patients with non-erosive reflux disease
However, most patients with heartburn or acid regurgitation have a normal esophagus on endoscopy, a condition known as NERD (non-erosive reflux disease
) or ENRD (endoscopy-negative reflux disease).
The search strategy consisted of a combination of the following MESH terms and text words: (gastroesophageal reflux disease, GERD, GORD, reflux esophagitis, RE, non-erosive reflux disease
, NERD, Barrett's esophagus, BE, erosive esophagitis, and EE); (Proton Pump Inhibitors, PPIs, omeprazole, lansoprazole, pantoprazole, rabeprazole, and esomeprazole); and (twice daily).
The above-mentioned criteria should be fulfilled for the preceding 3 months, with symptom onset of at least 6 month prior to diagnosis.18 Rome III Criteria for Non-Erosive Reflux Disease
(NERD) is an abnormal acid exposure or a positive symptoms-reflux association in the absence of macroscopic endoscopic signs of reflux oesophagitis.19
1 July 2011 - Anglo-Swedish AstraZeneca plc (LON: AZN, STO: AZN) said today that NEXIUM (esomeprazole magnesium) 10 mg and 20 mg capsules have obtained approval in Japan for the treatment of acid-related conditions including non-erosive reflux disease
(NERD), reflux esophagitis, and peptic ulcer disease (PUD).
This condition is known as NERD (non-erosive reflux disease
) or ENRD (endoscopic negative reflux disease).