The Non-ossifying Fibroma
: A Case Report and Review of the Literature.
Pathological types of tumors: nine cases of aneurysmal bone cyst, 11 cases of simple bone cyst, eight cases of bone fibrous dysplasia, nine cases of enchondroma, three cases of non-ossifying fibroma
and two cases of eosinophilic granuloma.
Caption: Figure 1 Proximal tibial non-ossifying fibroma
in a skeletally immature patient.
There are two forms of ABC- Primary (Occurring de novo) and secondary which complicates other benign and malignant conditions like-Fibrous Dysphasia, Osteoblastoma, Osteosarcoma, Chondroblastoma, Giant Cell tumour, chondromyxoid fibroma, non-ossifying fibroma
. [4,5,6,7] In our case all the causes of secondary ABC were ruled out.
Children Juxtaepiphysealregion 75% occur in the of the long bones.
The nonossifying fibroma is histologically very similar to the GCG which can, however, be differentiated from the latter since the granuloma- like aggregate of giant cells and the fibrous stroma found in GCG, are not typical features of non-ossifying fibroma
(metaphyseal fibrous defect) is a childhood disease and has typical radiological findings which are characterized by eccentric location, well demarcation and multilocular appearance.
Differential diagnosis of the findings included benign fibrous lesions of bone-like non-ossifying fibroma
and odontogenic fibroma, myxoma and chondromyxoid fibroma or even fibrosarcoma.
Table 1 Age (Years) Frequency Percent 1-10 2 4 11-20 12 24 21-30 12 24 31-40 7 14 41-50 6 12 51-60 6 12 61-70 3 6 71-80 2 4 Total 50 100 Table 2: Final Diagnosis Diagnosis Frequency Percent Osteosarcoma 8 16 GCT 4 8 Osteochondroma 3 6 ABC 1 2 Chondrogenic Osteosarcoma 1 2 Chondrosarcoma 3 6 Chordoma 2 3.3 Ewing's Sarcoma 1 2 Malignant Fibrous Histiocytoma 1 2 Malignant GCT 1 2 Malignant Mesenchymal Tumour 8 16 Osteoid Osteoma 2 4 Plasmacytoma 1 2 Simple Bone Cyst 2 4 Glomus 2 4 Haemangioma 1 2 Metastasis 4 8 Non-Ossifying Fibroma
1 2 Osteoma 1 2 Enchondroma 2 4 Langerhans Cell Histiocytosis 1 2 Total 50 100 Table 3: Musculoskeletal Tumours were Characterised by their Intensity Pattern to Allow a Specific Diagnosis in Certain Situations Tumour Origin T1W T2W I.
Incidental lesions typically found in children include unicameral bone cyst, fibrous dysplasia, and non-ossifying fibroma
. On the other hand, diagnoses specific to older patients include metastasis, multiple myeloma, enchondroma, and subchondral cysts.
(6) The tumours associated with oncogenic osteomalacia have been classified into 4 groups by Weidner and Santa-Cruz as primitive appearing mixed connective tissue tumours, osteoblastoma-like tumours, non-ossifying fibroma
like tumours and ossifying fibroma like tumours.
From the surgical pathology files of the State University of New York-Upstate Medical University Hospital in Syracuse, New York, from 1994 to 2009, 78 cases of giant cell lesions of bone and soft tissues, including 23 giant cell tumors of bone, 8 primary aneurysmal bone cysts, 15 tenosynovial giant cell tumors, 12 chondroblastomas, 4 giant cell reparative granulomas, 6 non-ossifying fibromas
, 2 fibrous dysplasias, 4 pigmented villonodular synovitides, and 4 osteosarcomas with giant cells, were retrieved.