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NHEJNon-Homologous End Joining
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References in periodicals archive ?
Lopez, "Double Strand Break Repair, one mechanism can hide another: Alternative non-homologous end joining," Cancer/Radiotherapie, vol.
Once Cas9 has cleaved the target DNA, two endogenous repair mechanisms, non-homologous end joining (NHEJ) and homology-directed repair (HDR), are triggered in response to the DNA break.
In the absence of HDR the cell will repair the cut using another process called non-homologous end joining (NHEJ) that leaves in its wake small insertions or deletions.
They demonstrated that normal BRIT1 aids repair of double-stranded DNA breaks by allowing access to two repair pathways: homologous recombination (HR) and non-homologous end joining (NHEC).
Double-strand breaks are predominately repaired by two mechanisms; template-directed high fidelity homologous recombination (HR) and low fidelity non-homologous end joining (NHEJ).