NNTH

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AcronymDefinition
NNTHNumber Needed to Harm
References in periodicals archive ?
Brexpiprazole for schizophrenia and as adjunct for major depressive disorder: a systematic review of the efficacy and safety profile for this newly approved antipsychotic--what is the number needed to treat, number needed to harm and likelihood to be helped or harmed?
The NNH (number needed to harm), however, is usually 1 or close to it.
Analogously, the number needed to harm would be the reciprocal of the difference between the proportion of the experimental group suffering a specified adverse outcome and the proportion of the control group having that outcome.
There are potentially grave consequences from such a practice change: the raw data from the study yield an NNH (number needed to harm) of 43 for using single-dose dexamethasone instead of 5-day prednisone.
The increased rate of stillbirth (hazard ratio, 1.14) among women with a primary C-section, compared with women with an initial spontaneous vaginal birth, translated to an absolute risk increase of 0.03% and a number needed to harm of 3,333.
Study results were analysed using number needed to treat (NNT) and number needed to harm (NNH).
Compared with people who had never smoked, those who had reported smoking regularly had a fourfold increased risk of bladder cancer, with a number needed to harm of 727.
Number Needed to Harm: Leslie Citrome, MD, MPH recently published a review of the registration data for the three SGAs of interest2.
To make this more understandable for the individual patient, doctors may describe the average number of patients they could treat with NSAIDS without causing one additional death--the NNH or "number needed to harm." If it is a big number, then you could give NSAIDS to lots of people before you would get one death due to the treatment.
A NNH (number needed to harm) analysis will say that you have to treat 50 patients with TCB to harm one more patient with hypertension as compared to using NCB.
An accompanying editorial explains that "the similarity of the number needed to treat (265) and the number needed to harm (210) has been the rationale for some guidelines that recommend not using aspirin for primary prevention." However, the USPTF guidelines call for a shared decision-making process with patients involving a careful discussion of "patient preferences regarding vascular and bleeding events," and colorectal cancer risk.
The weighted results over five years estimated 34 as the number needed to treat to avoid one cardiovascular event and 55 as the number needed to harm.