OAT3

AcronymDefinition
OAT3Organic Anion Transporter 3
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References in periodicals archive ?
The overall increase in expression of transporters, more explicitly the de novo expression of OAT3, as well as the correct cellular polarization and organization (e.g., tight junction formation), is testimony of the improved differentiation status of RPTEC/TERT1 in the matrigel sandwich.
Torres, "Time course of organic anion excretion in rats with bilateral ureteral obstruction: role of organic anion transporters (Oat1 and Oat3)," Nephron Physiology, vol.
Torres, "Renal expression and function of Oat1 and Oat3 in rats with vascular calcification," Pharmacology, vol.
In addition, thymoquinone has also been shown to increase the expression of various organic anion and cation transporters such as OAT1, OAT3, OCT1, and OCT2, which are necessary for the renal clearance of xenobiotic agents including toxins and commonly used drugs [140, 141].
The activated PKC[alpha] by angiotensin II downregulated Oat3 function, and GO6976, a specific PKC[alpha] inhibitor, reversed this inhibitory effect [17].
(2007) Downregulation of organic anion transporters OAT1 and OAT3 correlates with impaired secretion of para-aminohippurate after ischemic acute renal failure in rats.
Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) gene: consequences for pravastation pharmacokinetics.
Lithospermic acid, rosmarinic acid, salvianolic acid A, salvianolic acid B, and protocatechuic acid were reported to have inhibitory effects towards human organic anion transporter 1 (OAT1) and OAT3 with Kt values of 20.8 and 0.59, 0.35 and 0.55,5.6 and 0.16,22.2 and 19.8, and 13.4 and 81.8 [micro]M, respectively [54, 55].
Among antidiabetic drugs, OCT2 is involved in proximal tubular secretion of metformin, and OAT3 transports sitagliptin [9, 11].
The eight cell lines in the drug-transporter interactions service include P-glycoprotein (P-gp/MDR1), breast cancer resistant protein (BCRP), organic cation transporters 1& 2 (OCT1 & OCT2), organic anion transporter 3 (OAT3), organic anion transporting polypeptides 1B1 and 1B3 (OATP1B1 & OATP1B3), and multidrug resistance-associated protein 2 (MRP2).
2004), the marked difference between sexes in rats could be attributable to sex hormone regulation of the expression of certain organic anion transporters [OAT2 (Slc22a7), OAT3 (Slc22a8), and oatp1 (Slco1a1)] in the kidney (Kudo et al.